Arginine methylation and cytoplasmic mRNA fate: An exciting new partnership
Sign Up to like & getrecommendations! Published in 2021 at "Yeast"
DOI: 10.1002/yea.3653
Abstract: Posttranslational modifications play a crucial role in regulating gene expression. Among these modifications, arginine methylation has recently attracted tremendous attention due to its role in multiple cellular functions. This review discusses the recent advances that… read more here.
Keywords: arginine methylation; methylation; methylation cytoplasmic; mrna fate ... See more keywords
Cellular consequences of arginine methylation
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03140-2
Abstract: Arginine methylation is a ubiquitous post-translational modification. Three predominant types of arginine-guanidino methylation occur in Eukarya: mono (Rme1/MMA), symmetric (Rme2s/SDMA), and asymmetric (Rme2a/ADMA). Arginine methylation frequently occurs at sites of protein–protein and protein–nucleic acid interactions,… read more here.
Keywords: methylation; consequences arginine; arginine methylation; physiology ... See more keywords
Love is in the hair: arginine methylation of human hair proteins as novel cardiovascular biomarkers.
Sign Up to like & getrecommendations! Published in 2021 at "Amino acids"
DOI: 10.1007/s00726-021-03024-5
Abstract: Cardiovascular disease is the major cause of death worldwide. Extensive cardiovascular biomarkers are available using blood tests but very few, if any, investigations have described non-invasive tests for cardiovascular biomarkers based on readily available hair… read more here.
Keywords: human hair; hair; cardiovascular biomarkers; arginine methylation ... See more keywords
Arginine methylation of SKN-1 promotes oxidative stress resistance in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2019.101111
Abstract: Caenorhabditis elegans NRF (NF-E2-related factor)/CNC (Cap'n'collar) transcription factor, Skinhead-1 (SKN-1), is conservatively critical for promoting phase II detoxification gene expressions in response to oxidative stress. SKN-1 activity is controlled by well-known phosphorylation and recently-reported O-GlcNAcylation.… read more here.
Keywords: skn; caenorhabditis elegans; arginine methylation; oxidative stress ... See more keywords
Arginine Methylation of the PGC-1α C-Terminus Is Temperature-Dependent
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00363
Abstract: We set out to determine whether the C-terminus (amino acids 481–798) of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α, UniProt Q9UBK2), a regulatory metabolic protein involved in mitochondrial biogenesis, and respiration, is an arginine methyltransferase… read more here.
Keywords: methylation; temperature; terminus; arginine methylation ... See more keywords
Remote control of γc expression by arginine methylation
Sign Up to like & getrecommendations! Published in 2018 at "Nature Immunology"
DOI: 10.1038/s41590-018-0240-x
Abstract: Arginine methylation is a post-translational modification that controls the abundance of γc cytokine receptor on mature T cells by a post-transcriptional mechanism. read more here.
Keywords: remote control; methylation; arginine methylation; expression arginine ... See more keywords
Effectors and effects of arginine methylation
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Society Transactions"
DOI: 10.1042/bst20221147
Abstract: Arginine methylation is a ubiquitous and relatively stable post-translational modification (PTM) that occurs in three types: monomethylarginine (MMA), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). Methylarginine marks are catalyzed by members of the protein arginine… read more here.
Keywords: methylation; methylarginine marks; arginine methylation; effectors effects ... See more keywords
Arginine methylation is required for canonical Wnt signaling and endolysosomal trafficking
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1804091115
Abstract: Significance Endocytosis plays a fundamental role in Wnt signaling, leading to the sequestration of cytosolic GSK3 kinase inside multivesicular endosomes. Here we show an unexpected role for the enzyme protein arginine methyltransferase 1 (PRMT1) during… read more here.
Keywords: wnt signaling; wnt; canonical wnt; arginine methylation ... See more keywords
DeepGpgs: a novel deep learning framework for predicting arginine methylation sites combined with Gaussian prior and gated self-attention mechanism
Sign Up to like & getrecommendations! Published in 2023 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbad018
Abstract: Protein arginine methylation is an important posttranslational modification (PTM) associated with protein functional diversity and pathological conditions including cancer. Identification of methylation binding sites facilitates a better understanding of the molecular function of proteins. Recent… read more here.
Keywords: attention mechanism; methylation; gaussian prior; deep learning ... See more keywords
Arginine methylation expands the regulatory mechanisms and extends the genomic landscape under E2F control
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aaw4640
Abstract: Arginine methylation widens the mechanism of control by E2F1 from a transcription factor to a regulator of alternative RNA splicing. E2F is a family of master transcription regulators involved in mediating diverse cell fates. Here,… read more here.
Keywords: methylation; transcription; control; arginine methylation ... See more keywords
Arginine methylation of BRD4 by PRMT2/4 governs transcription and DNA repair
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.add8928
Abstract: BRD4 functions as an epigenetic reader and plays a crucial role in regulating transcription and genome stability. Dysregulation of BRD4 is frequently observed in various human cancers. However, the molecular details of BRD4 regulation remain… read more here.
Keywords: brd4; dna repair; prmt2; arginine methylation ... See more keywords