Arginine‐Rich Polymers with Pore‐Forming Capability Enable Efficient Intracellular Delivery via Direct Translocation Across Cell Membrane
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200371
Abstract: Efficient delivery of biomacromolecules or drugs across the cell membrane via endocytosis usually encounters inevitable entrapment in endosomes and subsequent degradation in lyso‐endosomes. To address this issue, a series of arginine‐rich cell penetrating polymers is… read more here.
Keywords: cell; cell membrane; across cell; arginine rich ... See more keywords
Conjugates of adenosine mimetics and arginine‐rich peptides serve as inhibitors and fluorescent probes but not as long‐lifetime photoluminescent probes for protein arginine methyltransferases
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Peptide Science"
DOI: 10.1002/psc.3456
Abstract: The conjugates of an adenosine mimetic and oligo‐l‐arginine or oligo‐d‐arginine (ARCs) were initially designed in our research group as inhibitors and photoluminescent probes targeting basophilic protein kinases. Here, we explored a panel of ARCs and… read more here.
Keywords: protein arginine; rich peptides; photoluminescent probes; arginine rich ... See more keywords
Arginine-rich peptide based nanoparticles with bridge-like structure: Enhanced cell penetration and tumor therapy effect
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DOI: 10.1016/j.cej.2020.125171
Abstract: Abstract Gene therapy has been recognized as one of the most potential approaches on cancer treatment field. Arginine-rich cell penetrating peptides have attracted enormous interests in gene delivery field due to their superior membrane translocation… read more here.
Keywords: arginine rich; like structure; arginine; structure ... See more keywords
Acidic-basic properties of arginine-rich peptide fragments derived from the human Pin1 protein
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DOI: 10.1016/j.molliq.2020.113379
Abstract: Abstract The effects of arginine residues in peptide sequences on their specific acid-base properties were investigated. Two short original fragments of the human Pin1 WW domain (hPin1 14–24; hPin1 15–23) and one single point mutation… read more here.
Keywords: arginine rich; properties arginine; acidic basic; human pin1 ... See more keywords
Affinity membrane adsorbers for binding arginine-rich proteins
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DOI: 10.1080/01496395.2016.1206934
Abstract: ABSTRACT Delivering protein chemotherapeutics into cancer cells is a challenge. Fusing the protein to an arginine-rich cell-penetrating peptide offers a possible solution. The goal of this work was to develop an affinity membrane for the… read more here.
Keywords: arginine rich; protein; affinity membrane; spectroscopy ... See more keywords
Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins
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DOI: 10.1126/scitranslmed.abq3215
Abstract: Arginine-rich dipeptide repeat proteins (R-DPRs), abnormal translational products of a GGGGCC hexanucleotide repeat expansion in C9ORF72, play a critical role in C9ORF72-related amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), the most common genetic form… read more here.
Keywords: rich dipeptide; repeat proteins; repeat; arginine rich ... See more keywords
Physiological and Pathological Function of Serine/Arginine-Rich Splicing Factor 4 and Related Diseases
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DOI: 10.1155/2018/3819719
Abstract: Serine/arginine-rich splicing factors (SRSFs) have one or two RNA recognition motifs in the N terminal and a serine/arginine-enriched domain in the C terminal. SRSFs are essential components of spliceosomes and are involved in alternative splicing,… read more here.
Keywords: arginine rich; physiological pathological; serine arginine; rich splicing ... See more keywords
Improving Cell Penetration of Gold Nanorods by Using an Amphipathic Arginine Rich Peptide
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s237820
Abstract: Introduction Gold nanorods are highly reactive, have a large surface-to-volume ratio, and can be functionalized with biomolecules. Gold nanorods can absorb infrared electromagnetic radiation, which is subsequently dispersed as local heat. Gold nanoparticles can be… read more here.
Keywords: gold nanorods; arginine rich; amphipathic arginine; cell ... See more keywords
Corrigendum: Prediction and Characterization of Cationic Arginine-Rich Plant Antimicrobial Peptide SM-985 From Teosinte (Zea mays ssp. mexicana)
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DOI: 10.3389/fmicb.2021.667085
Abstract: [This corrects the article DOI: 10.3389/fmicb.2020.01353.]. read more here.
Keywords: arginine rich; cationic arginine; rich plant; characterization cationic ... See more keywords
Cationic Arginine-Rich Peptides (CARPs): A Novel Class of Neuroprotective Agents With a Multimodal Mechanism of Action
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DOI: 10.3389/fneur.2020.00108
Abstract: There are virtually no clinically available neuroprotective drugs for the treatment of acute and chronic neurological disorders, hence there is an urgent need for the development of new neuroprotective molecules. Cationic arginine-rich peptides (CARPs) are… read more here.
Keywords: arginine rich; cationic arginine; class; peptides carps ... See more keywords
Identification and Regulation of Tomato Serine/Arginine-Rich Proteins Under High Temperatures
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DOI: 10.3389/fpls.2021.645689
Abstract: Alternative splicing is an important mechanism for the regulation of gene expression in eukaryotes during development, cell differentiation or stress response. Alterations in the splicing profiles of genes under high temperatures that cause heat stress… read more here.
Keywords: arginine rich; high temperatures; response; serine arginine ... See more keywords