Arginyl‐tRNA‐protein transferase 1 (ATE1) promotes melanoma cell growth and migration
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DOI: 10.1002/1873-3468.14376
Abstract: Arginyl‐tRNA‐protein transferase 1 (ATE1) catalyses N‐terminal protein arginylation, a post‐translational modification implicated in cell migration, invasion and the cellular stress response. Herein, we report that ATE1 is overexpressed in NRAS‐mutant melanomas, while it is downregulated… read more here.
Keywords: cell; arginyl trna; melanoma cell; ate1 ... See more keywords
Ablation of arginyl-tRNA-protein transferase in oligodendrocytes impairs central nervous system myelination.
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DOI: 10.1002/glia.24107
Abstract: Addition of arginine (Arg) from tRNA can cause major alterations of structure and function of protein substrates. This post-translational modification, termed protein arginylation, is mediated by the enzyme arginyl-tRNA-protein transferase 1 (Ate1). Arginylation plays essential… read more here.
Keywords: trna protein; arginyl trna; protein transferase; myelination ... See more keywords
Functional Interplay between Arginyl-tRNA Synthetases and Arginyltransferase
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DOI: 10.3390/ijms231710160
Abstract: Protein arginylation, mediated by arginyltransferase ATE1, is a posttranslational modification of emerging biological importance that consists of transfer of the amino acid Arg to protein and peptide substrates. ATE1 utilizes charged tRNAArg as the donor… read more here.
Keywords: arginyl trna; trna synthetases; arginylation; functional interplay ... See more keywords