Phosphine‐Catalyzed Synthesis and Cytotoxic Evaluation of Michael Adducts of the Sesquiterpene Lactone Arglabin
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DOI: 10.1002/cmdc.202400045
Abstract: A general method for chemo‐ and diastereoselective modification of anticancer natural product arglabin with nitrogen‐ and carbon‐centered pronucleophiles under the influence of nucleophilic phosphine catalysts was developed. The locked s‐cis‐geometry of α‐methylene‐γ‐butyrolactone moiety of arglabin… read more here.
Keywords: cell lines; sesquiterpene lactone; arglabin; phosphine catalyzed ... See more keywords