Loss of Arid1a and Pten in pancreatic ductal cells induces intraductal tubulopapillary neoplasm via the YAP/TAZ pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Gastroenterology"
DOI: 10.1053/j.gastro.2022.04.020
Abstract: KGROUND AND AIMS Pancreatic ductal adenocarcinoma (PDAC) arises from several types of premalignant lesions, including intraductal tubulopapillary neoplasm (ITPN); however, the molecular pathogenesis of ITPN remains unknown. METHODS We performed studies with Hnf1b-CreERT2; Ptenf/f; Arid1af/f… read more here.
Keywords: arid1a; ductal cells; itpn; taz pathway ... See more keywords
Abstract 6281: OTX-015 inhibits proliferation and migration in ARID1A-mutated bladder cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6281
Abstract: Background: ARID1A mutations (ARID1Amut) occur in up to 30% of metastatic bladder cancers (mBC) and have been associated with poorer response to standard treatments and shorter overall survival. We previously identified bromodomain and extraterminal (BET)… read more here.
Keywords: arid1a; proliferation migration; cancer; otx 015 ... See more keywords
Abstract LB044: Modeling the role of ARID1A in colon cancer using patient-derived organoids
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb044
Abstract: Loss-of-function (LOF) mutations in genes encoding subunits of SWI/SNF chromatin remodeling complexes are found in approximately 25% of human cancers. Colorectal cancers (CRC), the second leading cause of cancer related deaths, are particularly vulnerable to… read more here.
Keywords: role arid1a; arid1a colon; arid1a; cancer ... See more keywords
Abstract B30: ARID1A is a haploinsufficient tumor suppressor for N-Myc transformation of neural crest cells
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.pedca19-b30
Abstract: Large segmental chromosomal alterations are common to cancer and a feature of high-risk neuroblastoma (NBL). Though they are early or initiating events in cancer, including often being found in precancerous lesions, their contribution to tumorigenesis… read more here.
Keywords: tumor suppressor; transformation; cancer; arid1a ... See more keywords
The Role of ARID1A in the Nonestrogenic Modulation of IGF-1 Signaling
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DOI: 10.1158/1541-7786.mcr-21-0961
Abstract: Abstract Gaining pharmacologic access to the potential of ARID1A, a tumor suppressor protein, to mediate transcriptional control over cancer gene expression is an unresolved challenge. Retinoid X receptor ligands are pleiotropic, incompletely understood tools that… read more here.
Keywords: arid1a; igf signaling; growth; modulation ... See more keywords
Downregulated ARID1A by miR-185 Is Associated With Poor Prognosis and Adverse Outcomes in Colon Adenocarcinoma
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DOI: 10.3389/fonc.2021.679334
Abstract: AT-rich interaction domain 1A (ARID1A) is a tumor suppressor gene that mutates in several cancer types, including breast cancer, ovarian cancer, and colorectal cancer (CRC). In colon adenocarcinoma (COAD), the low expression of ARID1A was… read more here.
Keywords: mir 185; colon adenocarcinoma; expression; cancer ... See more keywords
ARID1A Downregulation Predicts High PD-L1 Expression and Worse Clinical Outcome in Patients With Gallbladder Cancer
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DOI: 10.3389/fonc.2022.787897
Abstract: Background Recent studies have confirmed that AT-rich interactive domain-containing protein 1A (ARID1A) plays a critical role in tumorigenesis, but its role in gallbladder cancer (GBC) remains unclear. Methods In total, 224 patients from Zhongshan Hospital… read more here.
Keywords: analysis; expression; gallbladder cancer; arid1a expression ... See more keywords
Endometrial Epithelial ARID1A Is Required for Uterine Immune Homeostasis during Early Pregnancy
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23116067
Abstract: A growing body of work suggests epigenetic dysregulation contributes to endometriosis pathophysiology and female infertility. The chromatin remodeling complex subunit AT-rich interaction domain 1A (ARID1A) must be properly expressed to maintain normal uterine function. Endometrial… read more here.
Keywords: arid1a; immune homeostasis; epithelial arid1a; pregnancy ... See more keywords