Prion-like domain mediated phase separation of ARID1A promotes oncogenic potential of Ewing’s sarcoma
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-51050-0
Abstract: Liquid-liquid phase separation (LLPS) facilitates the formation of membraneless organelles within cells, with implications in various biological processes and disease states. AT-rich interactive domain-containing protein 1A (ARID1A) is a chromatin remodeling factor frequently associated with… read more here.
Keywords: arid1a; prion like; phase separation; ewing sarcoma ... See more keywords
Loss of Arid1a and Pten in pancreatic ductal cells induces intraductal tubulopapillary neoplasm via the YAP/TAZ pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Gastroenterology"
DOI: 10.1053/j.gastro.2022.04.020
Abstract: KGROUND AND AIMS Pancreatic ductal adenocarcinoma (PDAC) arises from several types of premalignant lesions, including intraductal tubulopapillary neoplasm (ITPN); however, the molecular pathogenesis of ITPN remains unknown. METHODS We performed studies with Hnf1b-CreERT2; Ptenf/f; Arid1af/f… read more here.
Keywords: arid1a; ductal cells; itpn; taz pathway ... See more keywords
ARID1A regulates DNA repair through chromatin organization and its deficiency triggers DNA damage-mediated anti-tumor immune response
Sign Up to like & getrecommendations! Published in 2024 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkae233
Abstract: Abstract AT-rich interaction domain protein 1A (ARID1A), a SWI/SNF chromatin remodeling complex subunit, is frequently mutated across various cancer entities. Loss of ARID1A leads to DNA repair defects. Here, we show that ARID1A plays epigenetic… read more here.
Keywords: dna damage; arid1a; response; repair ... See more keywords
ARID1A regulates histone octamer transfer activity of human canonical BAF complex
Sign Up to like & getrecommendations! Published in 2025 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaf958
Abstract: Abstract Mutations that impact subunits of mammalian SWI/SNF (mSWI/SNF or BAF) chromatin remodeling complexes are found in over 20% of human cancers. Among these subunits, AT-rich interactive domain-containing protein 1A (ARID1A) is the most frequently… read more here.
Keywords: arid1a; histone octamer; octamer transfer; baf ... See more keywords
Abstract 6281: OTX-015 inhibits proliferation and migration in ARID1A-mutated bladder cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6281
Abstract: Background: ARID1A mutations (ARID1Amut) occur in up to 30% of metastatic bladder cancers (mBC) and have been associated with poorer response to standard treatments and shorter overall survival. We previously identified bromodomain and extraterminal (BET)… read more here.
Keywords: arid1a; proliferation migration; cancer; otx 015 ... See more keywords
Abstract LB044: Modeling the role of ARID1A in colon cancer using patient-derived organoids
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb044
Abstract: Loss-of-function (LOF) mutations in genes encoding subunits of SWI/SNF chromatin remodeling complexes are found in approximately 25% of human cancers. Colorectal cancers (CRC), the second leading cause of cancer related deaths, are particularly vulnerable to… read more here.
Keywords: role arid1a; arid1a colon; arid1a; cancer ... See more keywords
Abstract 1243: Shifted mSWI/SNF complex assembly and function underlie therapeutically targetable dependencies in endometrial carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-1243
Abstract: The mammalian SWI/SNF (mSWI/SNF) family of chromatin remodelers govern cell type-specific chromatin accessibility and gene expression and assemble as three distinct complexes: canonical BAF (cBAF), Polybromo-associated BAF (PBAF), and non-canonical BAF (ncBAF). ARID1A and ARID1B… read more here.
Keywords: arid1a; cancer; mswi snf; endometrial carcinoma ... See more keywords
Abstract B30: ARID1A is a haploinsufficient tumor suppressor for N-Myc transformation of neural crest cells
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.pedca19-b30
Abstract: Large segmental chromosomal alterations are common to cancer and a feature of high-risk neuroblastoma (NBL). Though they are early or initiating events in cancer, including often being found in precancerous lesions, their contribution to tumorigenesis… read more here.
Keywords: tumor suppressor; transformation; cancer; arid1a ... See more keywords
The Role of ARID1A in the Nonestrogenic Modulation of IGF-1 Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-21-0961
Abstract: Abstract Gaining pharmacologic access to the potential of ARID1A, a tumor suppressor protein, to mediate transcriptional control over cancer gene expression is an unresolved challenge. Retinoid X receptor ligands are pleiotropic, incompletely understood tools that… read more here.
Keywords: arid1a; igf signaling; growth; modulation ... See more keywords
Exome analysis of over 5000 esophagogastric cancers.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.4073
Abstract: 4073 Background: Esophagogastric cancers (EGCs) encompass a heterogenous group of cancers. The genomic drivers that overlap or differentiate among each cancer type are not well studied, despite the availability of therapies that target specific genetic… read more here.
Keywords: g2e3 t361fs; arid1a; esophagogastric cancers; tp53 r175h ... See more keywords
Downregulated ARID1A by miR-185 Is Associated With Poor Prognosis and Adverse Outcomes in Colon Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.679334
Abstract: AT-rich interaction domain 1A (ARID1A) is a tumor suppressor gene that mutates in several cancer types, including breast cancer, ovarian cancer, and colorectal cancer (CRC). In colon adenocarcinoma (COAD), the low expression of ARID1A was… read more here.
Keywords: mir 185; colon adenocarcinoma; expression; cancer ... See more keywords