ATARI trial: ATR inhibitor in combination with olaparib in gynecological cancers with ARID1A loss or no loss (ENGOT/GYN1/NCRI)
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2021-002973
Abstract: Background ARID1A (AT-rich interactive domain containing protein 1A) loss-of-function mutations have been reported in gynecological cancers, including rarer subtypes such as clear cell carcinoma. Preclinical studies indicate that ARID1A mutant cancers display sensitivity to ATR… read more here.
Keywords: combination; arid1a loss; trial; gynecological cancers ... See more keywords
Abstract LB-286: ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-lb-286
Abstract: Genes encoding subunits of SWI/SNF (BAF) chromatin remodeling complexes are collectively mutated in ~20% of all human cancers, but the mechanism by which these mutations promote tumorigenesis is unclear. In this study, we investigate the… read more here.
Keywords: arid1a loss; colon cancer; mice; cancer ... See more keywords
Morphological, clinical and molecular characteristics in ARID1a‑deficient microsatellite‑stable oesophageal adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Oncology letters"
DOI: 10.3892/ol.2023.13840
Abstract: Publications describe the relevance of the AT-rich interactive domain-containing protein 1A (ARID1a) mutation in gastric adenocarcinoma, which occurs predominantly in the microsatellite instable (MSI)- and Epstein-Barr virus (EBV)-associated subtypes. It is unclear whether potential therapeutic,… read more here.
Keywords: arid1a deficient; microsatellite stable; oesophageal adenocarcinoma; loss ... See more keywords