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   Articles with "arid1a mutations" as a keyword



Impact of frequent ARID1A mutations on protein stability provides insights into cancer pathogenesis

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-87103-7

Abstract: The ARID1A gene, frequently mutated in cancer, encodes the AT-rich interactive domain-containing protein 1 A, a key component of the chromatin remodeling SWI/SNF complex. The ARID1A protein features a conserved DNA-binding domain (ARID domain) of… read more here.

Keywords: cancer; stability; arid1a mutations; cancer pathogenesis ... See more keywords

ARID1A mutations in cancer development: mechanism and therapy.

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recommendations! Published in 2023 at "Carcinogenesis"

DOI: 10.1093/carcin/bgad011

Abstract: AT-Rich Interaction Domain 1A (ARID1A) is an important SWItch/Sucrose NonFermentation (SWI/SNF) chromatin remodeling complex subunit, and its coding gene has a high mutation frequency in many cancers. Current studies have reported that ARID1A mutational status… read more here.

Keywords: mutations cancer; arid1a mutations; cancer development; mechanism ... See more keywords

Abstract A047: ARID1A mutations drive metastasis of pancreatic neuroendocrine tumors and pancreatic adenocarcinomas by activation of NTN1/UNC5B signaling

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recommendations! Published in 2024 at "Cancer Research"

DOI: 10.1158/1538-7445.panca2023-a047

Abstract: ARID1A, a component of the SWI/SNF DNA chromatin remodeling complex, is recurrently mutated in many types of cancer. In pancreatic ductal adenocarcinomas (PDACs), mutations in ARID1A are found in 6-15% of cases, and ARID1A expression… read more here.

Keywords: cancer; mutations drive; arid1a mutations; pancreatic neuroendocrine ... See more keywords