Bioactivation mechanisms of Nâhydroxyaristolactams: Nitroreduction metabolites of aristolochic acids
Sign Up to like & getrecommendations! Published in 2019 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22321
Abstract: Aristolochic acids (AAs) are human nephrotoxins and carcinogens found in concoctions of Aristolochia plants used in traditional medicinal practices worldwide. Genotoxicity of AAs is associated with the formation of active species catalyzed by metabolic enzymes,… read more here.
Keywords: strains expressing; aristolochic acids; expressing human; mechanisms hydroxyaristolactams ... See more keywords
Herbal products containing aristolochic acids: A call to revisit the context of safety
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DOI: 10.1016/j.hermed.2021.100447
Abstract: Abstract Herbal products are used globally for their perceived health benefits, and as a complement to alternative therapy to Western medicines. Herbal products can be beneficial, although they can also be harmful in several circumstances.… read more here.
Keywords: call revisit; containing aristolochic; herbal products; acids call ... See more keywords
Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake.
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DOI: 10.1021/acs.jafc.8b04770
Abstract: Exposure to aristolochic acids (AAs) from Aristolochia plants is one of the major global causes of nephropathy, including Balkan endemic nephropathy (BEN); renal failure; and urothelial cancer. The high incidence of BEN on the Balkan… read more here.
Keywords: risk; aristolochic acids; exposure; incidence ben ... See more keywords
Chromosome-level genome assembly of Aristolochia contorta provides insights into the biosynthesis of benzylisoquinoline alkaloids and aristolochic acids
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DOI: 10.1093/hr/uhac005
Abstract: Abstract Aristolochic acids (AAs) and their derivatives are present in multiple Aristolochiaceae species that have been or are being used as medicinal materials. During the past decades, AAs have received increasing attention because of their… read more here.
Keywords: genome assembly; biosynthesis; aristolochic acids; genome ... See more keywords
Rapid and Simultaneous Quantification of Six Aristolochic Acids and Two Lignans in Asari Radix et Rhizoma Using Ultra-Performance Liquid Chromatography-Triple Quadrupole Tandem Mass Spectrometry
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Analytical Methods in Chemistry"
DOI: 10.1155/2022/5269545
Abstract: Asari Radix et Rhizoma (AR) is a widely-used Chinese herbal medicine containing multiple active lignans and rare nephrotoxic components-aristolochic acids derivatives (AAs). However, the current quality control method carried out by Chinese Pharmacopoeia has defects… read more here.
Keywords: performance liquid; aristolochic acids; quality; quality control ... See more keywords
Aristolochic Acids: Newly Identified Exposure Pathways of this Class of Environmental and Food-Borne Contaminants and its Potential Link to Chronic Kidney Diseases
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DOI: 10.3390/toxics7010014
Abstract: Aristolochic acids (AAs) are nitrophenanthrene carboxylic acids naturally produced by Aristolochia plants. These plants were widely used to prepare herbal remedies until AAs were observed to be highly nephrotoxic and carcinogenic to humans. Although the… read more here.
Keywords: aristolochic acids; potential link; chronic kidney; kidney diseases ... See more keywords