Inhibition of β-ARK1 Ameliorates Morphine-induced Tolerance and Hyperalgesia Via Modulating the Activity of Spinal NMDA Receptors
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DOI: 10.1007/s12035-017-0780-3
Abstract: Our previous study has proposed that increased presynaptic NMDARs activities play pivotal roles in the development of opioid tolerance and hyperalgesia, and blocking spinal NMDARs attenuates chronic morphine-induced synaptic plasticity and behavior. However, the cellular… read more here.
Keywords: morphine induced; tolerance; tolerance hyperalgesia; hyperalgesia ... See more keywords