An order restricted multi‐arm multi‐stage clinical trial design
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DOI: 10.1002/sim.9314
Abstract: One family of designs that can noticeably improve efficiency in later stages of drug development are multi‐arm multi‐stage (MAMS) designs. They allow several arms to be studied concurrently and gain efficiency by dropping poorly performing… read more here.
Keywords: multi arm; arm multi; multi stage; multi ... See more keywords
A Bayesian multi-arm multi-stage clinical trial design incorporating information about treatment ordering.
Sign Up to like & getrecommendations! Published in 2023 at "Statistics in medicine"
DOI: 10.1002/sim.9752
Abstract: Multi-Arm Multi-Stage (MAMS) designs can notably improve efficiency in later stages of drug development, but they can be suboptimal when an order in the effects of the arms can be assumed. In this work, we… read more here.
Keywords: multi arm; arm multi; multi stage; multi ... See more keywords
Simulation optimization for Bayesian multi-arm multi-stage clinical trial with binary endpoints
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2019.1577682
Abstract: ABSTRACT Multi-arm multi-stage designs, in which multiple active treatments are compared to a control and accumulated information from interim data are used to add or remove arms from the trial, may reduce development costs and… read more here.
Keywords: multi stage; arm multi; multi; multi arm ... See more keywords
Multi-arm multi-stage clinical trials for time-to-event outcomes.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biopharmaceutical statistics"
DOI: 10.1080/10543406.2021.1979575
Abstract: This paper investigates the use of a general multi-arm multi-stage (MAMS) approach for time-to-event outcomes that would streamline simultaneous comparison of a large number of promising therapies in clinical trials, thus significantly reducing the time… read more here.
Keywords: multi stage; multi; time; multi arm ... See more keywords
An open-label, single-arm, multi-institutional phase II trial of avelumab for recurrent, metastatic nasopharyngeal carcinoma.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.tps6092
Abstract: TPS6092Background: The majority of patients with nasopharyngeal carcinoma (NPC) present with locally advanced disease, with a predilection for early systemic dissemination. For patients who develop... read more here.
Keywords: multi institutional; label single; single arm; open label ... See more keywords