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   Articles with "arm phase" as a keyword



A stochastically curtailed single-arm phase II trial design for binary outcomes

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recommendations! Published in 2022 at "Journal of biopharmaceutical statistics"

DOI: 10.1080/10543406.2021.2009498

Abstract: ABSTRACT Phase II clinical trials are a critical aspect of the drug development process. With drug development costs ever increasing, novel designs that can improve the efficiency of phase II trials are extremely valuable. Phase… read more here.

Keywords: development; single arm; trial; design ... See more keywords

Efficacy of Shipixiaoji Granules, Lenvatinib, and Tislelizumab in Patients with Unresectable Hepatocellular Carcinoma: Protocol for a Prospective, Single-Arm, Phase Ⅱ Trial

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recommendations! Published in 2024 at "Natural Product Communications"

DOI: 10.1177/1934578x241305286

Abstract: Background and Aim Shipixiaoji granules (SPXJ) is traditional Chinese medicine that treats hepatocellular carcinoma (HCC). However, its efficacy in HCC is still unknown. This prospective study assessed the outcomes of using SPXJ combined with tyrosine… read more here.

Keywords: patients unresectable; shipixiaoji granules; single arm; arm phase ... See more keywords

A multi-centre, single arm, phase 2 trial of pembrolizumab in treatment-naïve patients with carcinoma of unknown primary site.

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recommendations! Published in 2024 at "Journal of Clinical Oncology"

DOI: 10.1200/jco.2024.42.16_suppl.2659

Abstract: 2659 Background: Cancer of unknown primary (CUP) represents a heterogeneous group of cancers that present with metastatic epithelial disease with no identifiable primary lesion at the time of diagnosis. Patients with poor prognostic features have… read more here.

Keywords: treatment; single arm; pembrolizumab; arm phase ... See more keywords

Transcatheter arterial chemoembolization plus atezolizumab and bevacizumab for unresectable hepatocellular carcinoma: a single-arm, phase 2 trial.

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recommendations! Published in 2022 at "Future oncology"

DOI: 10.2217/fon-2022-0188

Abstract: The therapeutic effect of transcatheter arterial chemoembolization (TACE) is limited for patients with hepatocellular carcinoma (HCC). Herein, we designed an open-label, single-arm phase II clinical trial to investigate the efficacy and safety of TACE combined… read more here.

Keywords: hepatocellular carcinoma; transcatheter arterial; single arm; trial ... See more keywords

TIDE: adjuvant tislelizumab plus donafenib combined with transarterial chemoembolization for high-risk hepatocellular carcinoma after surgery: protocol for a prospective, single-arm, phase II trial

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recommendations! Published in 2023 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2023.1138570

Abstract: Background The high recurrence rate of hepatocellular carcinoma (HCC) after surgery negatively affects the prognosis of patients. There is currently no widely accepted adjuvant therapy strategy for patients with HCC. A clinical study of effective… read more here.

Keywords: hepatocellular carcinoma; prospective single; single arm; trial ... See more keywords