From single-arm studies to externally controlled studies. Methodological considerations and guidelines.
Sign Up to like & getrecommendations! Published in 2019 at "Therapie"
DOI: 10.1016/j.therap.2019.11.007
Abstract: Single-arm studies are sometimes used as pivotal studies but they have methodological limitations which prevent them from obtaining the high level of reliability as for a randomised controlled study which remains the gold standard in… read more here.
Keywords: controlled studies; externally controlled; arm studies; single arm ... See more keywords
When are results of single-arm studies dramatic?
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Clinical Oncology"
DOI: 10.1038/s41571-020-00429-1
Abstract: Single-arm phase II trials can provide compelling results that facilitate the approval of a new therapy. Designing and interpreting single-arm studies based on four principles — instinct, comparative analysis, statistical soundness and like-for-like comparisons —… read more here.
Keywords: results single; arm studies; studies dramatic; single arm ... See more keywords
Network Meta-analysis on Disconnected Evidence Networks When Only Aggregate Data Are Available: Modified Methods to Include Disconnected Trials and Single-Arm Studies while Minimizing Bias
Sign Up to like & getrecommendations! Published in 2022 at "Medical Decision Making"
DOI: 10.1177/0272989x221097081
Abstract: Background Network meta-analysis (NMA) requires a connected network of randomized controlled trials (RCTs) and cannot include single-arm studies. Regulators or academics often have only aggregate data. Two aggregate data methods for analyzing disconnected networks are… read more here.
Keywords: reference prediction; reference; arm studies; single arm ... See more keywords