Prospective two‐arm study of the testicular function in patients with COVID‐19
Sign Up to like & getrecommendations! Published in 2022 at "Andrology"
DOI: 10.1111/andr.13159
Abstract: The COVID‐19 pandemic has led the international community to conduct extensive research into potential negative effects of the disease on multiple organs and systems in the human body. One of the most discussed areas is… read more here.
Keywords: function; two arm; prospective two; testicular function ... See more keywords
Promising zone two-stage design for a single-arm study with binary outcome.
Sign Up to like & getrecommendations! Published in 2023 at "Statistical methods in medical research"
DOI: 10.1177/09622802231164737
Abstract: Adaptive designs are increasingly used in clinical trials to assess the effectiveness of new drugs. For a single-arm study with a binary outcome, several adaptive designs were developed by using numerical search algorithms and the… read more here.
Keywords: study binary; single arm; adaptive designs; design ... See more keywords
Phase 2, randomized, 3-arm study of abiraterone acetate and prednisone (AAP), AAP plus degarelix (AAP+D), and degarelix (D) alone for patients (pts) with biochemically-recurrent prostate cancer (PC) following radical prostatectomy (RP).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.5016
Abstract: 5016Background: Androgen deprivation therapy (ADT) with GnRH analogs does not entirely suppress androgen signaling. AAP + ADT decreases blood and intratumoral testosterone (T) levels by ≥1 log, and... read more here.
Keywords: aap; study abiraterone; arm study; degarelix ... See more keywords
QUADRA: A phase 2, open-label, single-arm study to evaluate niraparib in patients (pts) with relapsed ovarian cancer (ROC) who have received ≥3 prior chemotherapy regimens.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.5514
Abstract: 5514Background: PARP inhibitors (PARPi) are approved as active treatment only for pts with BRCA mutations. The PARPi niraparib demonstrated increased PFS vs placebo in the maintenance setting of pl... read more here.
Keywords: arm study; quadra phase; phase open; label single ... See more keywords
Neoadjuvant Pembrolizumab and Chemotherapy in Resectable Esophageal Cancer: An Open-Label, Single-Arm Study (PEN-ICE)
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.849984
Abstract: Background In this single-arm study, the efficacy and safety of neoadjuvant pembrolizumab plus chemotherapy were evaluated in patients with resectable esophageal squamous cell carcinoma (ESCC). Methods This study included patients with ESCC of clinical stages… read more here.
Keywords: neoadjuvant pembrolizumab; single arm; chemotherapy; arm study ... See more keywords