Mechanism-Based Insights into Removing the Mutagenicity of Aromatic Amines by Small Structural Alterations.
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DOI: 10.1021/acs.jmedchem.1c00514
Abstract: Aromatic and heteroaromatic amines (ArNH2) are activated by cytochrome P450 monooxygenases, primarily CYP1A2, into reactive N-arylhydroxylamines that can lead to covalent adducts with DNA nucleobases. Hereby, we give hands-on mechanism-based guidelines to design mutagenicity-free ArNH2.… read more here.
Keywords: based insights; structural alterations; mechanism; arnh2 ... See more keywords