Targeting ARNT to attenuate renal fibrosis
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Nephrology"
DOI: 10.1038/s41581-018-0038-y
Abstract: © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature reviews | Nephrology Fibrosis is an important driver of end-stage organ failure and death in a variety of chronic diseases, including chronic… read more here.
Keywords: fk506; transcription; fibrosis; alk3 transcription ... See more keywords
FC 006PP2A PHOSPHATASE INHIBITION IS ANTI-FIBROTIC THROUGH SER77 PHOSPHORYLATION-MEDIATED ARNT/ARNT HOMODIMER FORMATION
Sign Up to like & getrecommendations! Published in 2021 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfab124.003
Abstract: Aryl hydrocarbon receptor nuclear translocator (ARNT) mediates anti-fibrotic activity in kidney and liver through induction of ALK3-receptor expression and subsequently increased Smad1/5/8 signaling. While expression of ARNT can be pharmacologically induced by sub-immunosuppressive doses of… read more here.
Keywords: arnt arnt; arnt; phosphorylation; activity ... See more keywords
Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies
Sign Up to like & getrecommendations! Published in 2022 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00503-21
Abstract: Aberrant alternative splicing (AS) of pre-mRNAs promotes the development and proliferation of cancerous cells. Accordingly, we had previously observed higher levels of the aryl hydrocarbon receptor nuclear translocator (ARNT) spliced variant isoform 1 in human… read more here.
Keywords: hydrocarbon receptor; receptor nuclear; lymphoid malignancies; arnt ... See more keywords