New small‐molecule compound Hu‐17 inhibits estrogen biosynthesis by aromatase in human ovarian granulosa cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3492
Abstract: Estrogen‐dependent cancers (breast, endometrial, and ovarian) are among the leading causes of morbidity and mortality in women worldwide. Aromatase is the main enzyme that catalyzes the biosynthesis of estrogen, which drives proliferation, and antiestrogens can… read more here.
Keywords: molecule compound; small molecule; estrogen; aromatase ... See more keywords
Lack of cross-resistance between non-steroidal and steroidal aromatase inhibitors in breast cancer patients: the potential role of the adipokine leptin
Sign Up to like & getrecommendations! Published in 2021 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-021-06399-x
Abstract: The aromatase inactivator exemestane may cause clinical disease stabilization following progression on non-steroidal aromatase inhibitors like letrozole in patients with metastatic breast cancer, indicating that additional therapeutic effects, not necessarily related to estrogen-suppression, may be… read more here.
Keywords: steroidal aromatase; aromatase inhibitors; breast cancer; aromatase ... See more keywords
Anastrozole-Induced Dermatitis: Report of a Woman with an Anastrozole-Associated Dermatosis and a Review of Aromatase Inhibitor-Related Cutaneous Adverse Events
Sign Up to like & getrecommendations! Published in 2020 at "Dermatology and Therapy"
DOI: 10.1007/s13555-020-00353-3
Abstract: Anastrozole is an aromatase inhibitor. Anastrozole competitively inhibits the aromatase enzyme, which synthesizes estrogen. It is used for estrogen receptor-positive breast cancers. A woman with breast cancer and anastrozole-induced dermatitis is described; the cutaneous side… read more here.
Keywords: aromatase inhibitor; induced dermatitis; anastrozole induced; aromatase ... See more keywords
Immunolocalisation des récepteurs aux œstrogènes et de l’aromatase au niveau de la prostate ventrale d’un rongeur saharien, Gerbillus tarabuli au cours du cycle de reproduction
Sign Up to like & getrecommendations! Published in 2018 at "Annales d'Endocrinologie"
DOI: 10.1016/j.ando.2018.06.184
Abstract: Gerbillus tarabuli est un rongeur saharien qui se reproduit selon un mode saisonnier caracterise par une periode de pleine activite testiculaire au printemps et une periode de regression et repos gonadique aux autres saisons. L’objectif… read more here.
Keywords: aromatase niveau; rongeur saharien; pour les; gerbillus tarabuli ... See more keywords
Gynécomastie par surexpression locale de l’aromatase : à propos de deux cas
Sign Up to like & getrecommendations! Published in 2018 at "Annales d'Endocrinologie"
DOI: 10.1016/j.ando.2018.06.366
Abstract: Introduction La gynecomastie peut etre due a une surexpression de l’aromatase, accrue dans certaines pathologies notamment neoplasiques ou plus rarement liee a une expression aberrante d’origine genetique. Le syndrome d’exces d’aromatase (AEXS), de transmission autosomique… read more here.
Keywords: locale aromatase; par; une surexpression; surexpression locale ... See more keywords
Immunohistochemical expression of aromatase cyp19a1a and cyp19a1b in the ovary and brain of zebrafish (Danio rerio) exposed to different concentrations of bisphenol A.
Sign Up to like & getrecommendations! Published in 2021 at "Aquatic toxicology"
DOI: 10.1016/j.aquatox.2021.105876
Abstract: Bisphenol A (BPA) is used to produce plastic and plastic derived products in multitude of daily utensils, being one of the industrial compounds most widely used. This endocrine disrupting chemical (EDCs) is a well-known environmental… read more here.
Keywords: different concentrations; cyp19a1a cyp19a1b; brain; expression ... See more keywords
Luteolin-7-methylether from Leonurus japonicus inhibits estrogen biosynthesis in human ovarian granulosa cells by suppression of aromatase (CYP19).
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173154
Abstract: Leonurus japonicus (motherwort) has been widely used to treat gynecological disorders, in which estrogen is often dysregulated, for a long time in China and other Asian countries. However, the chemical constituents and mechanisms underlying the… read more here.
Keywords: biosynthesis; estrogen biosynthesis; aromatase; xly29 ... See more keywords
Aromatase Inhibitor-Induced Inflammatory Myopathies: A Case Series.
Sign Up to like & getrecommendations! Published in 2021 at "Joint bone spine"
DOI: 10.1016/j.jbspin.2021.105308
Abstract: OBJECTIVE Aromatase inhibitors (AIs) are widely used in the adjuvant therapy setting in patients with estrogen receptor-positive breast cancer. Rheumatic side effects of AIs have been reported, including bone loss, arthralgias, myalgias, and tenosynovitis. There… read more here.
Keywords: inflammatory myopathies; case series; aromatase; cancer ... See more keywords
A comparison of two months pretreatment with GnRH agonists with or without an aromatase inhibitor in women with ultrasound-diagnosed ovarian endometriomas undergoing IVF.
Sign Up to like & getrecommendations! Published in 2019 at "Reproductive biomedicine online"
DOI: 10.1016/j.rbmo.2018.12.028
Abstract: RESEARCH QUESTION Does the addition of an aromatase inhibitor improve IVF outcomes in women with endometriomas when pretreating them with gonadotrophin-releasing hormone agonists? DESIGN Retrospective two-centre cohort study involving 126 women aged 21-39 years who… read more here.
Keywords: aromatase inhibitor; treatment; rate; aromatase ... See more keywords
Role of aromatase and radial glial cells in neurotoxin-induced dopamine neuron degeneration and regeneration.
Sign Up to like & getrecommendations! Published in 2017 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2016.02.011
Abstract: Radial glial cells (RGCs) in teleost brain are progenitor cells that express aromatase B and produce estrogens. Controversial data suggest that estrogens are critical for brain repair and neurogenesis in teleosts. Using a goldfish model… read more here.
Keywords: radial glial; glial cells; neurotoxin induced; aromatase ... See more keywords
Seasonal ovarian development in relation to the gonadotropins, steroids, aromatase and steroidogenic factor 1 (SF-1) in the banded gourami, Trichogaster fasciata.
Sign Up to like & getrecommendations! Published in 2018 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2018.07.014
Abstract: The endocrine regulation of gonadal development and annual variation of key sex steroids is the basic knowledge to understand the reproductive cycle of teleost fish. Present study was aimed to investigate the levels of gonadotropins… read more here.
Keywords: endocrinology; ovarian development; gonadotropins steroids; trichogaster fasciata ... See more keywords