Case Study in 21st‐Century Ecotoxicology: Using In Vitro Aromatase Inhibition Data to Predict Reproductive Outcomes in Fish In Vivo
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology and Chemistry"
DOI: 10.1002/etc.5504
Abstract: To reduce the use of intact animals for chemical safety testing, while ensuring protection of ecosystems and human health, there is a demand for new approach methodologies (NAMs) that provide relevant scientific information at a… read more here.
Keywords: aromatase inhibition; inhibition; vitro aromatase; case study ... See more keywords
Using adverse outcome pathways to contextualise (Q)SAR predictions for reproductive toxicity - A case study with aromatase inhibition.
Sign Up to like & getrecommendations! Published in 2022 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2022.01.004
Abstract: The development and application of (quantitative) structure-activity relationship ((Q)SAR) models for reproductive toxicology remains challenging, given the complexity of the endpoint and the risks associated with subsequent decision making. Adverse outcome pathways (AOPs) organise knowledge… read more here.
Keywords: aromatase inhibition; adverse outcome; toxicology; outcome pathways ... See more keywords
Milicia excelsa (Moraceae) reversed the effects of letrozole-induced aromatase inhibition in rats with polycystic ovary syndrome
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Complementary and Integrative Medicine"
DOI: 10.1515/jcim-2022-0352
Abstract: Abstract Objectives Polycystic ovary syndrome (PCOS) is an endocrinopathy affecting 5–20% of women of childbearing age. There is no single drug for the treatment of PCOS and current therapies have significant side effects. This study… read more here.
Keywords: aromatase inhibition; pcos; polycystic ovary; ovary syndrome ... See more keywords
Evaluation of Multifunctional Hybrid Analogs for Stilbenes, Chalcones and Flavanones.
Sign Up to like & getrecommendations! Published in 2018 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520617666170530091223
Abstract: AIMS In this study, discovery of novel anticancer agents acting by more than one mechanism was aimed. METHOD For this purpose, eleven previously synthesized simple-stilbene, chalcone, flavanone derivatives and 31 novel stilbene-fused chalcones and stilbene-fused… read more here.
Keywords: cancer; fused chalcones; stilbene fused; aromatase inhibition ... See more keywords