Effect of Fractional Carbon Dioxide vs Sham Laser on Sexual Function in Survivors of Breast Cancer Receiving Aromatase Inhibitors for Genitourinary Syndrome of Menopause
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.55697
Abstract: Key Points Question Is vaginal laser treatment safe and effective for genitourinary syndrome of menopause in survivors of breast cancer receiving aromatase inhibitors? Findings In this randomized clinical trial with 84 participants in 2 parallel… read more here.
Keywords: aromatase inhibitors; receiving aromatase; breast cancer; survivors breast ... See more keywords
Aromatase inhibitors and the incidence of Parkinson disease: A population-based cohort study.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer"
DOI: 10.1002/cncr.34208
Abstract: BACKGROUND Current guidelines recommend the treatment of hormone receptor-positive breast cancer with aromatase inhibitors (AIs) and tamoxifen in the adjuvant setting. Some observational studies have raised concerns that tamoxifen may be associated with an increased… read more here.
Keywords: cancer; breast cancer; parkinson disease; aromatase inhibitors ... See more keywords
Polyphenolic natural products and natural product–inspired steroidal mimics as aromatase inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Research Reviews"
DOI: 10.1002/med.21536
Abstract: The discovery of biologically active polyphenolic natural products, including chalcones, stilbenes, flavanones, and isoflavones as steroidal mimics has proven to be a subject of considerable importance in medicine. Some of these natural compounds have been… read more here.
Keywords: natural products; aromatase inhibitors; natural product; polyphenolic natural ... See more keywords
Metronomic capecitabine combined with aromatase inhibitors for new chemoendocrine treatment of advanced breast cancer: a phase II clinical trial
Sign Up to like & getrecommendations! Published in 2018 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-018-5024-3
Abstract: PurposeThis study was designed to determine the safety and clinical efficacy of metronomic chemotherapy combined with aromatase inhibitors (AIs) for hormone receptor (HR)-positive advanced breast cancer (ABC) patients who cannot tolerate conventional-dose chemotherapy.MethodsPostmenopausal patients with… read more here.
Keywords: combined aromatase; aromatase inhibitors; treatment; breast cancer ... See more keywords
Lack of cross-resistance between non-steroidal and steroidal aromatase inhibitors in breast cancer patients: the potential role of the adipokine leptin
Sign Up to like & getrecommendations! Published in 2021 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-021-06399-x
Abstract: The aromatase inactivator exemestane may cause clinical disease stabilization following progression on non-steroidal aromatase inhibitors like letrozole in patients with metastatic breast cancer, indicating that additional therapeutic effects, not necessarily related to estrogen-suppression, may be… read more here.
Keywords: steroidal aromatase; aromatase inhibitors; breast cancer; aromatase ... See more keywords
Design, synthesis, in vitro and in silico studies of some novel thiazole-dihydrofuran derivatives as aromatase inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105123
Abstract: Aromatase inhibitors used against hormone-dependent breast cancer, especially in post-menopausal women, are very susceptible to the development of resistance due to their limited number and long-term use. In this study, it is aimed to obtain… read more here.
Keywords: thiazole dihydrofuran; aromatase inhibitors; vitro; cell ... See more keywords
Efficacy of extended adjuvant therapy with aromatase inhibitors in early breast cancer among common clinicopathologically-defined subgroups: A systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer treatment reviews"
DOI: 10.1016/j.ctrv.2017.08.008
Abstract: BACKGROUND Randomized controlled trials (RCTs) have shown improvements in breast cancer outcomes from extending treatment with aromatase inhibitors (AIs) beyond the initial 5years after diagnosis. Consistency of this effect in common clinicopathologically defined subgroups was… read more here.
Keywords: aromatase inhibitors; common clinicopathologically; breast cancer; clinicopathologically defined ... See more keywords
Synthesis, structure-activity relationships and molecular docking studies of phenyldiazenyl sulfonamides as aromatase inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113737
Abstract: The exploration of innovative aromatase inhibitors represents an important approach for the identification of new therapeutic treatments of breast cancer. In this respect, a series of phenyldiazenyl sulfonamides was designed, synthesized and tested. Compounds 3b,… read more here.
Keywords: activity relationships; aromatase inhibitors; phenyldiazenyl sulfonamides; structure activity ... See more keywords
Evaluating the role of aromatase inhibitors in the treatment of low-grade endometrial stromal sarcomas
Sign Up to like & getrecommendations! Published in 2022 at "Gynecologic Oncology Reports"
DOI: 10.1016/j.gore.2022.100980
Abstract: Highlights • AIs may offer prolonged disease stability even in metastatic ESS, but response rates are modest.• After disease progression on one AI, some patients may benefit from trial of a different AI.• Optimal duration… read more here.
Keywords: role aromatase; low grade; aromatase inhibitors; inhibitors treatment ... See more keywords
Art of prevention: The importance of dermatologic care when using aromatase inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Women's Dermatology"
DOI: 10.1016/j.ijwd.2021.07.002
Abstract: As of January 2021, there are more than 3.8 million women in the United States with a history of breast cancer. The current standard of care for breast cancer involves surgical resection, radiation therapy, adjuvant… read more here.
Keywords: cancer; art prevention; therapy; aromatase inhibitors ... See more keywords
Aromatase inhibitors: The unexpected breast cancer treatment.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of geriatric oncology"
DOI: 10.1016/j.jgo.2019.07.024
Abstract: OBJECTIVE Suboptimal adherence with endocrine treatment for breast cancer is influenced by a number of factors but remains poorly understood. We sought to describe the prior knowledge about and expectations of breast cancer treatments among… read more here.
Keywords: aromatase inhibitors; treatment; breast cancer; cancer ... See more keywords