Regioselective Annulation of Allenylphosphine Oxides with Aromatic Amides under Ruthenium(II) Catalysis.
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DOI: 10.1021/acs.orglett.2c01125
Abstract: Engaging allenes in transition-metal-catalyzed C-H bond activation strategy is immensely promising to access high-value scaffolds. However, such a reaction manifold remains largely elusive using cheap and sustainable ruthenium catalysis. We disclose an unprecedented ruthenium-catalyzed (4… read more here.
Keywords: aromatic amides; allenylphosphine oxides; ruthenium catalysis; regioselective annulation ... See more keywords
Palladium-Catalyzed [3 + 2] Annulation of Aromatic Amides with Maleimides through Dual C-H Activation.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00251
Abstract: A palladium-catalyzed [3 + 2] annulation of substituted aromatic amides with maleimides providing tricyclic heterocyclic molecules in good to moderate yields through weak carbonyl chelation is reported. The reaction proceeds via a dual C-H bond… read more here.
Keywords: catalyzed annulation; palladium catalyzed; annulation; amides maleimides ... See more keywords
Rh(I)-Catalyzed Alkylation of ortho-C-H Bonds in Aromatic Amides with Maleimides.
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DOI: 10.1021/acs.orglett.7b02135
Abstract: An alkylation of C-H bonds with maleimides by a rhodium-catalyzed reaction of aromatic amides containing an 8-aminoquinoline moiety as the directing group is reported. Various N-substituents in the maleimide, including methyl, ethyl, cyclohexyl, benzyl, and… read more here.
Keywords: ortho bonds; aromatic amides; alkylation ortho; catalyzed alkylation ... See more keywords
Cobalt(II)-Catalyzed Acyloxylation of C-H Bonds in Aromatic Amides with Carboxylic Acids.
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DOI: 10.1021/acs.orglett.7b04020
Abstract: The cobalt(II)-catalyzed acyloxylation of C-H bonds in aromatic amides containing an 8-aminoquinoline moiety as the directing group with carboxylic acids is reported. Various carboxylic acids including aromatic and aliphatic carboxylic acids are applicable to the… read more here.
Keywords: catalyzed acyloxylation; carboxylic acids; aromatic amides; cobalt catalyzed ... See more keywords
Cobalt-Catalyzed Direct C-H Thiolation of Aromatic Amides with Disulfides: Application to the Synthesis of Quetiapine.
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DOI: 10.1021/acs.orglett.8b02812
Abstract: A direct C(sp2)-H thiolation of aromatic amides with disulfides was developed. The coupling reaction proceeds between the thioether radical and cobaltacycle intermediate. This method exhibits a relatively broad substrate scope and high functional group compatibility.… read more here.
Keywords: amides disulfides; aromatic amides; cobalt catalyzed; catalyzed direct ... See more keywords
Direct Acyloxylation of C(sp2)-H and C(sp2)-X (X = Cl, Br) Bonds in Aromatic Amides Using Copper Bromide and 2-(4,5-Dihydro-oxazol-2-yl)-phenylamine.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b00306
Abstract: Here we reported a method for Cu2+-catalyzed ortho-acyloxylation of either the C(sp2)-H or C(sp2)-X (X = Cl, Br) bond of aromatic amides with carboxylic acid, especially olefine acids, to obtain corresponding products in good yields… read more here.
Keywords: direct acyloxylation; acyloxylation sp2; aromatic amides; sp2 sp2 ... See more keywords