Gene therapy improves brain white matter in aromatic l‐amino acid decarboxylase deficiency
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Neurology"
DOI: 10.1002/ana.25467
Abstract: Children with aromatic l‐amino acid decarboxylase (AADC) deficiency suffer from severe motor dysfunction. Restoration of dopamine levels in the putamen by gene therapy has led to significant improvement in motor function. This study explored brain… read more here.
Keywords: acid decarboxylase; aromatic amino; amino acid; gene therapy ... See more keywords
Evaluation of characteristic metabolites of aromatic amino acids in patients with HIV infection at different stages of disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24795
Abstract: Acquired immune deficiency syndrome (AIDS), human immunodeficiency virus (HIV) infection, and antiretroviral therapy are usually associated with metabolic disorders. Screening for biomarkers to evaluate the progression of metabolic disorders is important for the diagnosis and… read more here.
Keywords: infection; patients hiv; aromatic amino; evaluation characteristic ... See more keywords
Time-restricted feeding affects transcriptomic profiling of hypothalamus in pigs through regulating aromatic amino acids metabolism.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12256
Abstract: BACKGROUND Time-restricted feeding (TRF) is an effective means that can efficiently administer the metabolism and health of animal and humans. However, the effect of TRF on hypothalamic function remains unclear yet. RESULTS Results showed that… read more here.
Keywords: amino acids; metabolism; time restricted; hypothalamus ... See more keywords
Targeted metabolomics analysis of aromatic amino acids and their gut microbiota-host cometabolites in rat serum and urine by liquid chromatography coupled with tandem mass spectrometry.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of separation science"
DOI: 10.1002/jssc.201700368
Abstract: Gut microbiota-host cometabolites are closely related to various diseases. Monitoring dynamic changes of cometabolites can provide a more comprehensive understanding of pathophysiology. Here, a novel liquid chromatography-tandem mass spectrometry method was performed for the analysis… read more here.
Keywords: host cometabolites; amino acids; gut microbiota; aromatic amino ... See more keywords
Intraputaminal Gene Delivery in Two Patients with Aromatic L‐Amino Acid Decarboxylase Deficiency
Sign Up to like & getrecommendations! Published in 2023 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.13685
Abstract: Aromatic l‐amino acid decarboxylase deficiency (AADCD) is a rare, early‐onset, dyskinetic encephalopathy mostly reflecting a defective synthesis of brain dopamine and serotonin. Intracerebral gene delivery (GD) provided a significant improvement among AADCD patients (mean age,… read more here.
Keywords: acid decarboxylase; decarboxylase deficiency; amino acid; aromatic amino ... See more keywords
Aromatic L‐amino acid decarboxylase deficiency in 17 Mainland China patients: Clinical phenotype, molecular spectrum, and therapy overview
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1143
Abstract: Aromatic L‐amino acid decarboxylase deficiency (AADCD) is a rare, autosomal recessive inherited disorder which is characterized by neurological and vegetative symptoms. To date, only 130 patients with AADCD have been reported worldwide. read more here.
Keywords: acid decarboxylase; aromatic amino; amino acid; decarboxylase deficiency ... See more keywords
Characterization of two new aromatic amino acid lyases from actinomycetes for highly efficient production of p-coumaric acid
Sign Up to like & getrecommendations! Published in 2020 at "Bioprocess and Biosystems Engineering"
DOI: 10.1007/s00449-020-02325-5
Abstract: p-Coumaric acid (p-CA) is a bioactive natural product and an important industrial material for pharmaceuticals and nutraceuticals. It can be synthesized from deamination of l-tyrosine by tyrosine ammonia lyase (TAL). In this work, we discovered… read more here.
Keywords: sas tal; amino acid; coumaric acid; sts tal ... See more keywords
The interaction between methionine and two aromatic amino acids is an abundant and multifunctional motif in proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2019.07.018
Abstract: Many types of non-covalent interactions give rise to a protein's natural structure and function. One such interaction involves an aromatic amino acid (phenylalanine (Phe), tryptophan (Trp), or tyrosine (Tyr)) and the sulfur of methionine (Met),… read more here.
Keywords: protein; amino; aromatic interaction; met aromatic ... See more keywords
Obesity Impairs Short-Term and Working Memory through Gut Microbial Metabolism of Aromatic Amino Acids.
Sign Up to like & getrecommendations! Published in 2020 at "Cell metabolism"
DOI: 10.1016/j.cmet.2020.09.002
Abstract: The gut microbiome has been linked to fear extinction learning in animal models. Here, we aimed to explore the gut microbiome and memory domains according to obesity status. A specific microbiome profile associated with short-term… read more here.
Keywords: working memory; obesity; short term; aromatic amino ... See more keywords
Aromatic Amino Acid-Mediated Perovskite Nanocrystals: Fluorescence Tuning and Morphological Evolution.
Sign Up to like & getrecommendations! Published in 2022 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.2c01021
Abstract: Lead halide perovskites with high fluorescent and tunable morphology appeared at the forefront of materials chemistry because of their corresponding impressive optoelectronic properties. The current advancement of metal halide perovskites put forward the functional and… read more here.
Keywords: perovskite nanocrystals; chemistry; amino acid; aromatic amino ... See more keywords
Substituted Dihydroisoquinolinones by Iodide-Promoted Cyclocarbonylation of Aromatic α-Amino Acids.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b03551
Abstract: Imidazolidinone derivatives of a range of aromatic α-amino acids, on treatment with phosgene and potassium iodide, undergo a mild Bischler-Napieralski-style cyclocarbonylation reaction that generates a tricyclic lactam by insertion of a C═O group between amino… read more here.
Keywords: amino; amino acids; cyclocarbonylation; substituted dihydroisoquinolinones ... See more keywords