Fast Kinetics Reveals Rate-Limiting Oxidation and the Role of the Aromatic Cage in the Mechanism of the Nicotine-Degrading Enzyme NicA2.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00855
Abstract: In Pseudomonas putida, the flavoprotein nicotine oxidoreductase (NicA2) catalyzes the oxidation of (S)-nicotine to N-methyl-myosmine, which is nonenzymatically hydrolyzed to pseudooxynicotine. Structural analysis reveals a monoamine oxidase (MAO)-like fold with a conserved FAD-binding domain and… read more here.
Keywords: mechanism; nica2; aromatic cage; half ... See more keywords
Aromatic cage-like B46: existence of the largest decagonal holes in stable atomic clusters
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DOI: 10.1039/c7ra02870a
Abstract: The most stable form of B46 has a cage-like structure containing two hexagonal, two heptagonal and two decagonal holes. The intriguing presence of decagonal holes is a remarkable breakthrough since such large holes have never… read more here.
Keywords: cage like; like b46; aromatic cage; atomic clusters ... See more keywords
Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d2sc05944d
Abstract: Plant homeodomain fingers (PHD-fingers) are a family of reader domains that can recruit epigenetic proteins to specific histone modification sites. Many PHD-fingers recognise methylated lysines on histone tails and play... read more here.
Keywords: target aromatic; cage phd; cyclic peptides; reader ... See more keywords