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Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2018.11.001
Abstract: Non-covalent interactions between naturally occurring aromatic residues have been widely exploited as scaffold stabilizing agents in de novo designed peptides and in Nature - inspired structures. Our understanding of the factors driving aromatic interactions and…
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Keywords:
historical perspective;
interactions hairpin;
scaffold stability;
stability historical ... See more keywords
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Published in 2020 at "Journal of Medicinal Chemistry"
DOI: 10.2210/pdb6kof/pdb
Abstract: Indoleamine 2,3-dioxygenase (IDO1) inhibitors are speculated to be useful in cancer immunotherapy, but a phase III clinical trial of the most advanced IDO1 inhibitor, epacadostat, did not meet its primary end point and was abandoned.…
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Keywords:
indoleamine dioxygenase;
aromatic interactions;
sulfur aromatic;
unique sulfur ... See more keywords
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Published in 2021 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.733441
Abstract: Antibiotic resistance is emerging as a hot issue with the abuse and overuse of antibiotics, and the shortage of effective antimicrobial agents against multidrug resistant bacteria creates a huge problem to treat the threatening nosocomial…
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Keywords:
antimicrobial amphiphiles;
infection;
trp rich;
aromatic interactions ... See more keywords