Ni-Catalyzed Asymmetric Hydrogenation of Aromatic Ketoacids for the Synthesis of Chiral Lactones.
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DOI: 10.1021/acs.orglett.2c00608
Abstract: A highly efficient Ni-catalyzed asymmetric hydrogenation of aromatic γ- and δ-ketoacids has been developed, affording a series of γ- and δ-aryl lactones in high yields and excellent enantioselectivities (≤98% ee). The hydrogenation could occur smoothly… read more here.
Keywords: aromatic ketoacids; hydrogenation; asymmetric hydrogenation; catalyzed asymmetric ... See more keywords