An improved quantum mechanical model of P450-mediated aromatic oxidation
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DOI: 10.1016/j.dmpk.2017.11.213
Abstract: The Cytochrome P450 enzymes (P450s) are a large family of monooxygenases involved in the metabolism of drugs via oxidative reactions such as C-H bond hydroxylation, epoxidation and heteroatom oxidation. It has become increasingly important, within… read more here.
Keywords: p450 mediated; aromatic oxidation; metabolism; model ... See more keywords