Altered Peptide Self-Assembly and Co-Assembly with DNA by Modification of Aromatic Residues.
Sign Up to like & getrecommendations! Published in 2021 at "ChemMedChem"
DOI: 10.1002/cmdc.202100440
Abstract: Aromatic residues are widely used as building blocks for driving self-assemblies in natural and designer biomaterials. The non-covalent interactions involving aromatic rings determine proteins' structure and biofunction. Here, we studied the effects of changes in the proximity of… read more here.
Keywords: self assembly; aromatic residues; peptide self; self ... See more keywords
The return of the rings: Evolutionary convergence of aromatic residues in the intrinsically disordered regions of RNA‐binding proteins for liquid–liquid phase separation
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4317
Abstract: Aromatic residues appeared relatively late in the evolution of protein sequences to stabilize the globular proteins' folding core and are less in the intrinsically disordered regions (IDRs). Recent advances in protein liquid–liquid phase separation (LLPS)… read more here.
Keywords: intrinsically disordered; liquid phase; aromatic residues; disordered regions ... See more keywords
Differential Effects of Aromatic Residues on Amyloid Formation and Cytotoxicity of Human IAPP.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00267
Abstract: Islet amyloid polypeptide (IAPP) is a 37-residue polypeptide hormone secreted by the pancreatic β-cells. IAPP plays a role in glycemic regulation, but in the pre-type-2 diabetic state, it aggregates to form an islet amyloid. The… read more here.
Keywords: amyloid formation; aromatic residues; role; formation cytotoxicity ... See more keywords
18F-Trifluoromethanesulfinate Enables Direct C–H 18F-Trifluoromethylation of Native Aromatic Residues in Peptides
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b11709
Abstract: 18F labeling strategies for unmodified peptides with [18F]fluoride require 18F-labeled prosthetics for bioconjugation more often with cysteine thiols or lysine amines. Here we explore selective radical chemistry to target aromatic residues applying C–H 18F-trifluoromethylation. We… read more here.
Keywords: aromatic residues; direct 18f; peptides 18f; 18f trifluoromethanesulfinate ... See more keywords
Atomic insight into short helical peptide comprised of consecutive multiple aromatic residues.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc01038k
Abstract: The occurrence of sequential multiple aromatic residues in a helical sequence is rare compared to the β-sheet rich structure. Here, using helix promoting α-aminoisobutyric acid (Aib) residues, we unravel atomistic details of the helical secondary… read more here.
Keywords: aromatic residues; insight short; multiple aromatic; atomic insight ... See more keywords
Consecutive Aromatic Residues Are Required for Improved Efficacy of β-Sheet Breakers
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23095247
Abstract: Alzheimer’s disease is a fatal neurodegenerative malady which up to very recently did not have approved therapy modifying its course. After controversial approval of aducanumab (monoclonal antibody clearing β-amyloid plaques) by FDA for use in… read more here.
Keywords: aromatic residues; consecutive aromatic; required improved; sheet breakers ... See more keywords
Aromatic Residues on the Side Surface of Cry4Ba-Domain II of Bacillus thuringiensis subsp. israelensis Function in Binding to Their Counterpart Residues on the Aedes aegypti Alkaline Phosphatase Receptor
Sign Up to like & getrecommendations! Published in 2023 at "Toxins"
DOI: 10.3390/toxins15020114
Abstract: Receptor binding is a prerequisite process to exert the mosquitocidal activity of the Cry4Ba toxin of Bacillus thuringiensis subsp. israelensis. The beta-sheet prism (domain II) and beta-sheet sandwich (domain III) of the Cry4Ba toxin have… read more here.
Keywords: aromatic residues; domain; cry4ba; cry4ba toxin ... See more keywords