Aromatic scaffold-integrated hybrids of estradiol and benzoxazol-2-ones: synthesis and in vitro anticancer activity of N-substituted regioisomeric pairs
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DOI: 10.1039/d5ra01977j
Abstract: Molecular hybridization often leads to derivatives with better pharmacokinetic properties and different biological effects than their parent compounds. Several N-substituted benzoxazolone – estradiol chimeras sharing a common benzene ring were prepared by N-alkylation or N-arylation… read more here.
Keywords: vitro anticancer; aromatic scaffold; anticancer activity; scaffold integrated ... See more keywords