Clinical characteristics of Asian patients with sleep apnea with low arousal threshold and sleep structure change with continuous positive airway pressure
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DOI: 10.1007/s11325-020-02235-6
Abstract: Low respiratory arousal threshold (ArTH) has been observed to be prevalent in patients with obstructive sleep apnea (OSA), and is associated with poor adherence to continuous positive airway pressure (CPAP) treatment. This study aimed to… read more here.
Keywords: low arth; cpap titration; sleep structure; clinical characteristics ... See more keywords
Addition of zolpidem to combination therapy with atomoxetine‐oxybutynin increases sleep efficiency and the respiratory arousal threshold in obstructive sleep apnoea: A randomized trial
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DOI: 10.1111/resp.14110
Abstract: Atomoxetine combined with oxybutynin (Ato‐Oxy) has recently been shown to reduce obstructive sleep apnoea (OSA) severity by >60%. However, Ato‐Oxy also modestly reduced the respiratory arousal threshold, which may decrease sleep quality/efficiency. We sought to… read more here.
Keywords: sleep apnoea; obstructive sleep; efficiency; arousal ... See more keywords
Effect of Pimavanserin on the Respiratory Arousal Threshold from Sleep: A Randomized Trial.
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DOI: 10.1513/annalsats.202205-419oc
Abstract: RATIONALE A low respiratory arousal threshold is a key endotype responsible for obstructive sleep apnea (OSA) pathogenesis. Pimavanserin is an antiserotoninergic capable of suppressing CO2-mediated arousals without affecting the respiratory motor response in animal models,… read more here.
Keywords: arousal threshold; effect; osa severity; arousal ... See more keywords