Articles with "aroyl indoles" as a keyword



Photo by shalone86 from unsplash

Developing C2-Aroyl Indoles as Novel Inhibitors of IDO1 and Understanding Their Mechanism of Inhibition via Mass Spectroscopy, QM/MM Calculations and Molecular Dynamics Simulation

Sign Up to like & get
recommendations!
Published in 2021 at "Frontiers in Chemistry"

DOI: 10.3389/fchem.2021.691319

Abstract: Indoleamine-2,3-dioxygenase (IDO1) and tryptophan dioxygenases are two heme based metalloenzymes that catalyze the tryptophan oxidation reaction by inserting molecular dioxygen to cleave the pyrrole ring. The mechanism of such ring cleavage reaction is of carcinogenic… read more here.

Keywords: aroyl indoles; mechanism; mass spectroscopy; spectroscopy ... See more keywords