Cellular and pathophysiological consequences of Arp2/3 complex inhibition: role of inhibitory proteins and pharmacological compounds
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03128-y
Abstract: The actin-related protein complex 2/3 (Arp2/3) generates branched actin networks important for many cellular processes such as motility, vesicular trafficking, cytokinesis, and intercellular junction formation and stabilization. Activation of Arp2/3 requires interaction with actin nucleation-promoting… read more here.
Keywords: arp2; cellular pathophysiological; inhibitory proteins; inhibition ... See more keywords
The C-terminus of Ubl4A is critical for pro-death activity and association with the Arp2/3 complex.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.08.123
Abstract: Ubl4A is a small ubiquitin-like protein involved in diverse cellular functions. We have shown that Ubl4A is critical for survival of the starvation-mediated cell death in vivo. The underlying mechanism for this is through interaction with… read more here.
Keywords: arp2 complex; death; arp2; terminus ... See more keywords
Redefining the Role of the Arp2/3 Complex: Regulation of Morphology at the Leading Edge
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.120
Abstract: Arp2/3 complex is thought to be the primary protrusive force generator in cell migration by controlling the assembly and turnover of the branched filament network that pushes the leading edge of moving cells forward. However,… read more here.
Keywords: arp2 complex; arp2; leading edge; cell ... See more keywords
Molecular mechanism of Arp2/3 complex inhibition by Arpin
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28112-2
Abstract: Positive feedback loops involving signaling and actin assembly factors mediate the formation and remodeling of branched actin networks in processes ranging from cell and organelle motility to mechanosensation. The Arp2/3 complex inhibitor Arpin controls the… read more here.
Keywords: arp2 complex; inhibition arpin; mechanism; arp2 ... See more keywords
Arp2/3 nucleates F-actin coating of fusing insulin granules in pancreatic β cells to control insulin secretion
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.236794
Abstract: ABSTRACT F-actin dynamics are known to control insulin secretion, but the point of intersection with the stimulus-secretion cascade is unknown. Here, using multiphoton imaging of β cells isolated from Lifeact-GFP transgenic mice, we show that… read more here.
Keywords: insulin; arp2; secretion; actin coating ... See more keywords
Identification of Arp2/3 Complex Subunits as Prognostic Biomarkers for Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.690151
Abstract: The actin-related protein 2/3 complex (Arp2/3) is a major actin nucleator that has been widely reported and plays an important role in promoting the migration and invasion of various cancers. However, the expression patterns and… read more here.
Keywords: hepatocellular carcinoma; arp2; hcc; actr3 arpc2 ... See more keywords