Arp2/3 complex and Mps3 are required for regulation of ribosome biosynthesis in the secretory stress response
Sign Up to like & getrecommendations! Published in 2017 at "Yeast"
DOI: 10.1002/yea.3221
Abstract: Secretory defects cause transcriptional repression of ribosome biogenesis in Saccharomyces cerevisiae. However, the molecular mechanism underlying secretory defect‐induced transcriptional repression of ribosome biogenesis remains to be fully elucidated. In this study, we demonstrated that the… read more here.
Keywords: arp2 complex; complex mps3; response; secretory ... See more keywords
Does self-organized criticality drive leading edge protrusion?
Sign Up to like & getrecommendations! Published in 2018 at "Biophysical Reviews"
DOI: 10.1007/s12551-018-0484-6
Abstract: Arp2/3 complex nucleates dendritic actin networks and plays a pivotal role in the formation of lamellipodia at the leading edge of motile cells. Mouse fibroblasts lacking functional Arp2/3 complex have the characteristic smooth, veil-like lamellipodial… read more here.
Keywords: self organized; arp2 complex; leading edge; edge ... See more keywords
The C-terminus of Ubl4A is critical for pro-death activity and association with the Arp2/3 complex.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.08.123
Abstract: Ubl4A is a small ubiquitin-like protein involved in diverse cellular functions. We have shown that Ubl4A is critical for survival of the starvation-mediated cell death in vivo. The underlying mechanism for this is through interaction with… read more here.
Keywords: arp2 complex; death; arp2; terminus ... See more keywords
Redefining the Role of the Arp2/3 Complex: Regulation of Morphology at the Leading Edge
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.120
Abstract: Arp2/3 complex is thought to be the primary protrusive force generator in cell migration by controlling the assembly and turnover of the branched filament network that pushes the leading edge of moving cells forward. However,… read more here.
Keywords: arp2 complex; arp2; leading edge; cell ... See more keywords
Cytoskeleton regulation: Distinct steps in Arp2/3 complex activation
Sign Up to like & getrecommendations! Published in 2022 at "Current Biology"
DOI: 10.1016/j.cub.2022.01.071
Abstract: During branched actin assembly, several factors are necessary to activate the Arp2/3 complex. A new study reveals the importance of WASP- and actin-filament-mediated activation of the Arp2/3 complex in the assembly of functional actin networks. read more here.
Keywords: steps arp2; regulation distinct; activation; cytoskeleton regulation ... See more keywords
PRR11 induces filopodia formation and promotes cell motility via recruiting ARP2/3 complex in non-small cell lung cancer cells
Sign Up to like & getrecommendations! Published in 2021 at "Genes and Diseases"
DOI: 10.1016/j.gendis.2021.02.012
Abstract: Abstract Filopodia, a finger-like structure and actin-rich plasma-membrane protrusion at the leading edge of the cell, has important roles in cell motility. However, the mechanisms of filopodia generation are not well-understood via the actin-related protein… read more here.
Keywords: arp2 complex; cell; filopodia formation; cell motility ... See more keywords
Molecular mechanism of Arp2/3 complex inhibition by Arpin
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28112-2
Abstract: Positive feedback loops involving signaling and actin assembly factors mediate the formation and remodeling of branched actin networks in processes ranging from cell and organelle motility to mechanosensation. The Arp2/3 complex inhibitor Arpin controls the… read more here.
Keywords: arp2 complex; inhibition arpin; mechanism; arp2 ... See more keywords
Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR+ endosome trafficking
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-08357-4
Abstract: T cell receptor (TCR) signaling is important for T cell homeostasis and function. However, how surface TCR levels are regulated and its biological significance on T cells remains largely unknown. Here, we show that the… read more here.
Keywords: arp2 complex; tcr levels; cell homeostasis; surface tcr ... See more keywords
Structure of Arp2/3 complex at a branched actin filament junction resolved by single-particle cryo-electron microscopy
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2202723119
Abstract: Significance Actin filament nucleation by Arp2/3 complex must be triggered by activators like WASP family proteins. Understanding how WASP proteins activate Arp2/3 complex has been a major challenge due to a lack of high-resolution structures… read more here.
Keywords: structure; microscopy; actin filament; arp2 complex ... See more keywords
Mechanism of actin filament branch formation by Arp2/3 complex revealed by a high-resolution cryo-EM structureof the branch junction
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2206722119
Abstract: Significance Arp2/3 complex is a protein assembly with seven subunits that forms actin filament branches on the sides of preexisting “mother” actin filaments. This process generates growing actin filaments for cellular locomotion and intracellular movements.… read more here.
Keywords: resolution cryo; branch; actin filament; arp2 complex ... See more keywords
Tumor microtubes connect pancreatic cancer cells in an Arp2/3 complex-dependent manner
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e19-11-0605
Abstract: Actin-based tubular connections between cells have been observed in many cell types. Termed “tunneling nanotubes (TNTs),” “membrane nanotubes,” “tumor microtubes (TMTs),” or “cytonemes,” these protrusions interconnect cells in dynamic networks. Structural features in these protrusions… read more here.
Keywords: cancer cells; cancer; arp2 complex; tumor microtubes ... See more keywords