Kaempferol suppresses cell migration through the activation of the ERK signaling pathways in ARPE‐19 cells
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Toxicology"
DOI: 10.1002/tox.22686
Abstract: Kaempferol is a flavonoid with anticancer and anti‐metastasis activity in different cancer‐cell lines. However, the underlying mechanisms by which kaempferol acts on human retinal pigment epithelial (ARPE‐19) cells remain unclear. In this study, we demonstrated… read more here.
Keywords: arpe cells; signaling pathways; cell migration; kaempferol ... See more keywords
Silencing of miR-23a attenuates hydrogen peroxide (H2O2) induced oxidative damages in ARPE-19 cells by upregulating GLS1: an in vitro study
Sign Up to like & getrecommendations! Published in 2020 at "Cytotechnology"
DOI: 10.1007/s10616-020-00431-6
Abstract: Oxidative damages contributes to age-related macular degeneration (AMD) caused vision blindness, but the molecular mechanisms are still largely unknown. This study managed to investigate this issue by conducting in vitro experiments. Oxidative stress were evaluated… read more here.
Keywords: arpe cells; oxidative damages; induced oxidative; gls1 ... See more keywords
Lutein activates downstream signaling pathways of unfolded protein response in hyperglycemic ARPE-19 cells.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174663
Abstract: We have earlier demonstrated that lutein effectively prevents hyperglycemia generated sustained oxidative stress in ARPE-19 cells by activating Nrf2 (nuclear factor erythroid 2-related factor 2) signaling. Since evidence portrays an intricate connection between ER (endoplasmic reticulum)… read more here.
Keywords: hyperglycemia; arpe; arpe cells; lutein ... See more keywords
Casein kinase I inhibitor D4476 influences autophagy and apoptosis in chloroquine-induced adult retinal pigment epithelial-19 cells.
Sign Up to like & getrecommendations! Published in 2022 at "Experimental eye research"
DOI: 10.1016/j.exer.2022.109004
Abstract: The antimalarial drug chloroquine (CQ) induces retinopathy, a disorder characterized by lysosomotropic alteration. In this study, we examined whether D4476 (4-(4-(2,3-dihydrobenzo [1,4] dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl) benzamide), a specific casein kinase 1 inhibitor, alleviate CQ-induced retinopathy in adult… read more here.
Keywords: kinase inhibitor; casein kinase; arpe cells; adult retinal ... See more keywords
Amelioration of hyperglycemia-induced oxidative damage in ARPE-19 cells by myricetin derivatives isolated from Syzygium malaccense
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2020.103844
Abstract: Abstract Myricetin derivatives (F2) isolated from leaf extract of Syzygium malaccense (Malay apple) which contains myricitrin predominantly, could potentially serve as functional food ingredient based on previous findings. The present study aimed to investigate the… read more here.
Keywords: arpe cells; derivatives isolated; myricetin derivatives; induced oxidative ... See more keywords
Sodium tanshinone IIA sulfonate protects ARPE-19 cells against oxidative stress by inhibiting autophagy and apoptosis
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33552-2
Abstract: Oxidative stress in retinal pigment epithelium (RPE) is considered to be a major contributor to the development and progression of age-related macular degeneration (AMD). Previous investigations have shown that sodium tanshinone IIA sulfonate (STS) can… read more here.
Keywords: arpe cells; cells oxidative; sodium tanshinone; apoptosis ... See more keywords
Tanshinone IIA Inhibits VEGF Secretion and HIF-1α Expression in Cultured Human Retinal Pigment Epithelial Cells under Hypoxia
Sign Up to like & getrecommendations! Published in 2017 at "Current Eye Research"
DOI: 10.1080/02713683.2017.1355467
Abstract: ABSTRACT Purpose: The current work intends to study the activity of tanshinone IIA on secretion of vascular endothelial growth factor (VEGF) and expression of hypoxia inducible factor 1α (HIF-1α) in human retinal pigment epithelial cells… read more here.
Keywords: arpe cells; secretion; tanshinone iia; expression ... See more keywords
Lipofuscin-mediated photic stress inhibits phagocytic activity of ARPE-19 cells; effect of donors’ age and antioxidants
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Research"
DOI: 10.1080/10715762.2017.1380307
Abstract: Abstract The risk of chronic oxidative stress in the retinal pigment epithelium (RPE) increases with age due to accumulation of the photoreactive age pigment lipofuscin (LFG). Here, we asked whether sublethal and weakly lethal photic… read more here.
Keywords: arpe cells; age; phagocytic activity; stress ... See more keywords
Evaluation of microRNA responses in ARPE-19 cells against the oxidative stress
Sign Up to like & getrecommendations! Published in 2018 at "Cutaneous and Ocular Toxicology"
DOI: 10.1080/15569527.2017.1355314
Abstract: Abstract Purpose: This study aimed to determine microRNA (miRNA) expression profile of human retinal pigment epithelium cell (ARPE-19) against the oxidative stress induced by hydrogen peroxide (H2O2). Methods: ARPE-19 cells were incubated with different concentrations… read more here.
Keywords: arpe cells; mir mir; mir; microrna ... See more keywords
Inhibition of galectin-3 ameliorates high-glucose-induced oxidative stress and inflammation in ARPE-19 cells
Sign Up to like & getrecommendations! Published in 2022 at "Cutaneous and Ocular Toxicology"
DOI: 10.1080/15569527.2022.2081701
Abstract: Abstract Purpose Retinal pigment epithelium (RPE) has been found to be participated in the pathogenesis of DR in recent years. Galectin-3 (Gal-3) is involved in many diabetic complications and ophthalmological diseases. However, the role of… read more here.
Keywords: arpe cells; high glucose; oxidative stress; expression ... See more keywords
Autophagy induction decreases protein aggregation in response to polyphenolic pinosylvin and heat shock exposures in ARPE-19 cells
Sign Up to like & getrecommendations! Published in 2017 at "Acta Ophthalmologica"
DOI: 10.1111/j.1755-3768.2017.0t005
Abstract: Purpose Impaired protein degradation and increased protein aggregation in retinal pigment epithelium (RPE) cells associate with the age-related macular degeneration (AMD) pathology. Heat shock proteins (Hsps) refold misfolded proteins and attempt to prevent the accumulation… read more here.
Keywords: heat shock; arpe cells; pinosylvin heat; heat ... See more keywords