In-vitro and in-vivo combined effect of ARQ 092, an AKT inhibitor, with ARQ 087, a FGFR inhibitor
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DOI: 10.1097/cad.0000000000000486
Abstract: The PI3K/AKT pathway plays an important role in the initiation and progression of cancer, and the drug development efforts targeting this pathway with therapeutic interventions have been advanced by academic and industrial groups. However, the… read more here.
Keywords: akt; arq 092; inhibitor; vitro vivo ... See more keywords
In vivo efficacy of the AKT inhibitor ARQ 092 in Noonan Syndrome with multiple lentigines-associated hypertrophic cardiomyopathy
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DOI: 10.1371/journal.pone.0178905
Abstract: Noonan Syndrome with Multiple Lentigines (NSML, formerly LEOPARD syndrome) is an autosomal dominant "RASopathy" disorder manifesting in congenital heart disease. Most cases of NSML are caused by catalytically inactivating mutations in the protein tyrosine phosphatase… read more here.
Keywords: arq 092; noonan syndrome; akt inhibitor; mice ... See more keywords