Allosteric interactions in the parathyroid hormone GPCR–arrestin complex formation
Sign Up to like & getrecommendations! Published in 2020 at "Nature chemical biology"
DOI: 10.1038/s41589-020-0567-0
Abstract: Peptide ligands of class B G-protein-coupled receptors act via a two-step binding process, but the essential mechanisms that link their extracellular binding to intracellular receptor–arrestin interactions are not fully understood. Using NMR, crosslinking coupled to… read more here.
Keywords: pth; arrestin complex; parathyroid hormone; arrestin ... See more keywords
Biased agonists of the chemokine receptor CXCR3 differentially signal through Gαi:β-arrestin complexes
Sign Up to like & getrecommendations! Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.abg5203
Abstract: G protein–coupled receptors (GPCRs) are the largest family of cell surface receptors and signal through the proximal effectors, G proteins and β-arrestins, to influence nearly every biological process. The G protein and β-arrestin signaling pathways… read more here.
Keywords: arrestin complex; arrestin complexes; arrestin; protein ... See more keywords