Residency time of agonists does not affect the stability of GPCR–arrestin complexes
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DOI: 10.1111/bph.15846
Abstract: The interaction of arrestins with G‐protein coupled receptors (GPCRs) desensitizes agonist‐dependent receptor responses and often leads to receptor internalization. GPCRs that internalize without arrestin have been classified as “class A” GPCRs whereas “class B” GPCRs… read more here.
Keywords: agonists affect; residency time; affect stability; arrestin ... See more keywords
Noncanonical scaffolding of Gαi and β-arrestin by G protein–coupled receptors
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DOI: 10.1126/science.aay1833
Abstract: Another way for GPCRs to signal G protein–coupled receptors (GPCRs) normally transmit signals by coupling to heterotrimeric guanine nucleotide–binding proteins (G proteins) or by binding β-arrestin proteins. Smith et al. provide evidence for another mechanism,… read more here.
Keywords: protein; arrestin complexes; arrestin; protein coupled ... See more keywords
Biased agonists of the chemokine receptor CXCR3 differentially signal through Gαi:β-arrestin complexes
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DOI: 10.1126/scisignal.abg5203
Abstract: G protein–coupled receptors (GPCRs) are the largest family of cell surface receptors and signal through the proximal effectors, G proteins and β-arrestins, to influence nearly every biological process. The G protein and β-arrestin signaling pathways… read more here.
Keywords: arrestin complex; arrestin complexes; arrestin; protein ... See more keywords