Discovery and Binding Mechanism of Pyrazoloisoquinoline-Based Novel β-Arrestin Inverse Agonists of the Kappa-Opioid Receptor.
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DOI: 10.1021/acs.jmedchem.3c00064
Abstract: Chronic exposure to stress or unwanted stimuli has been known to activate kappa opioid receptor/dynorphin (KOR/DYN) systems, which could induce depressive states and develop into some psychiatric disorders. Here, we report the first discovery of… read more here.
Keywords: pyrazoloisoquinoline based; opioid receptor; kappa opioid; arrestin inverse ... See more keywords