Phosphoproteomic Analysis of Dopamine D2 Receptor Signaling Reveals Interplay of G Protein- and β-Arrestin-Mediated Effects.
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DOI: 10.1021/acs.jproteome.2c00707
Abstract: Leveraging biased signaling of G protein-coupled receptors has been proposed as a promising strategy for the development of drugs with higher specificity. However, the consequences of selectively targeting G protein- or β-arrestin-mediated signaling on cellular… read more here.
Keywords: dopamine receptor; protein arrestin; arrestin mediated; analysis ... See more keywords
Arrestin-mediated desensitization enables intraneuronal olfactory discrimination in Caenorhabditis elegans
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DOI: 10.1073/pnas.2116957119
Abstract: Significance Nematode worms rely primarily on olfaction for information about the external world and encode over 1,000 olfactory receptors in their genomes. All olfactory receptors in the worm appear to signal through the same few… read more here.
Keywords: intraneuronal olfactory; desensitization; olfactory receptors; discrimination ... See more keywords
In Vitro Analyses of Spinach-Derived Opioid Peptides, Rubiscolins: Receptor Selectivity and Intracellular Activities through G Protein- and β-Arrestin-Mediated Pathways
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DOI: 10.3390/molecules26196079
Abstract: Activated opioid receptors transmit internal signals through two major pathways: the G-protein-mediated pathway, which exerts analgesia, and the β-arrestin-mediated pathway, which leads to unfavorable side effects. Hence, G-protein-biased opioid agonists are preferable as opioid analgesics.… read more here.
Keywords: opioid receptor; arrestin mediated; opioid peptides; opioid receptors ... See more keywords
Evaluation of the Intracellular Signaling Activities of κ-Opioid Receptor Agonists, Nalfurafine Analogs; Focusing on the Selectivity of G-Protein- and β-Arrestin-Mediated Pathways
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DOI: 10.3390/molecules27207065
Abstract: Opioid receptors (ORs) are classified into three types (μ, δ, and κ), and opioid analgesics are mainly mediated by μOR activation; however, their use is sometimes restricted by unfavorable effects. The selective κOR agonist nalfurafine… read more here.
Keywords: nalfurafine analogs; intracellular signaling; arrestin mediated; selectivity ... See more keywords