β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy
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DOI: 10.26508/lsa.202101183
Abstract: GPCRs regulator, β-arrestin1, is increased in FTLD-tau patients, is required for β2-adrenergic receptor and metabotropic glutamate receptor 2-induced tau phosphorylation, promotes tau aggregation by impairing autophagy, and destabilizes microtubule dynamics, whereas genetic reduction in β-arrestin1… read more here.
Keywords: tau; pathogenic tau; gpcrs; promotes tauopathy ... See more keywords