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   Articles with "arrestin2" as a keyword



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Mdm2-mediated ubiquitination of β-arrestin2 in the nucleus occurs in a Gβγ- and clathrin-dependent manner.

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recommendations! Published in 2020 at "Biochemical pharmacology"

DOI: 10.1016/j.bcp.2020.114049

Abstract: The fate and activity of β-arrestin2, a key player in the regulation of desensitization and endocytosis of G protein-coupled receptors (GPCRs), are regulated by mouse double minute 2 homolog (Mdm2)-mediated ubiquitination. However, details of the… read more here.

Keywords: arrestin2; mdm2 mediated; mdm2; clathrin dependent ... See more keywords
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Mitigation of dexamethasone-induced nephrotoxicity by modulating the activity of adrenergic receptors: Implication of Wnt/β-arrestin2/β-catenin pathway.

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recommendations! Published in 2022 at "Life sciences"

DOI: 10.1016/j.lfs.2022.120304

Abstract: The present study aimed to investigate the role of α and β-adrenergic receptors (βARs) in mediation or modulation of the dexamethasone-induced nephrotoxicity by using different pharmacological interventions. Nephrotoxicity was induced by subcutaneous injection of dexamethasone… read more here.

Keywords: catenin; dexamethasone induced; arrestin2; induced nephrotoxicity ... See more keywords
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Targeting the Dvl-1/β-arrestin2/JNK3 interaction disrupts Wnt5a-JNK3 signaling and protects hippocampal CA1 neurons during cerebral ischemia reperfusion

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recommendations! Published in 2018 at "Neuropharmacology"

DOI: 10.1016/j.neuropharm.2018.03.006

Abstract: &NA; It is well known that Wnt5a activation plays a pivotal role in brain injury and &bgr;‐arrestin2 induces c‐Jun N‐terminal kinase (JNK3) activation is involved in neuronal cell death. Nonetheless, the relationship between Wnt5a and… read more here.

Keywords: arrestin2; jnk3 signaling; bgr arrestin2; jnk3 ... See more keywords
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β‑arrestin2 promotes 5‑FU‑induced apoptosis via the NF‑κB pathway in colorectal cancer.

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recommendations! Published in 2018 at "Oncology reports"

DOI: 10.3892/or.2018.6340

Abstract: It has been demonstrated that β‑arrestin2 is involved in the initiation and development of many types of cancers. However, its role in colorectal cancer (CRC) remains poorly understood. The present study investigated the role of… read more here.

Keywords: arrestin2; induced apoptosis; colorectal cancer; crc ... See more keywords