Abstract C005: Arylsulfatase B inhibits progression of malignant melanoma by COP1-mediated apoptosis in syngeneic and humanized mouse models
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DOI: 10.1158/1535-7163.targ-25-c005
Abstract: The enzyme Arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) removes the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate (C4S) and is required for C4S degradation in mammalian cells. Congenital, inactivating mutations of ARSB are the cause… read more here.
Keywords: malignant melanoma; cop1; arsb; arylsulfatase ... See more keywords
Abstract 1395: Constitutive photomorphogenesis (COP)-1 leads to apoptosis in B16F10 metastatic melanoma model
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DOI: 10.1158/1538-7445.am2025-1395
Abstract: The E3 ubiquitin ligase Constitutive Photomorphogenesis (COP)-1 inhibits UVB-induced light activation in plants by interaction with UV Receptor (UVR)8 and effects on hypocotyl elongation (HY)5-induced growth. UVB is recognized as a causative factor in human… read more here.
Keywords: constitutive photomorphogenesis; cop1; arsb; melanoma ... See more keywords
Decline in arylsulfatase B leads to increased invasiveness of melanoma cells
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DOI: 10.18632/oncotarget.13751
Abstract: Arylsulfatase B (ARSB; N-acetylgalactosamine 4-sulfatase) is reduced in several malignancies, but levels in melanoma have not been investigated previously. Experiments were performed in melanoma cell lines to determine ARSB activity and impact on melanoma invasiveness.… read more here.
Keywords: melanoma; arsb; increased invasiveness; invasiveness melanoma ... See more keywords