Acute toxicity of intratracheal arsenic trioxide instillation in rat lungs
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3841
Abstract: This study investigated the acute toxicity of different concentrations of arsenic trioxide (As2O3; ATO) on rat lungs. In total, 160 Wistar rats were randomly divided into the control, low‐, medium‐ and high‐dose groups, which were… read more here.
Keywords: arsenic trioxide; rat lungs; acute toxicity; toxicity ... See more keywords
Arsenic trioxide-induced autophagy affected the antioxidant capacity and apoptosis rate of chicken hepatocytes.
Sign Up to like & getrecommendations! Published in 2022 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2022.109821
Abstract: Arsenic has recently received widespread attention due to its high toxicological effects on multiple animals; however, the mechanism underlying this toxicity is unclear. We investigated the damaging effects of arsenic trioxide (ATO) on hepatocytes and… read more here.
Keywords: apoptosis; antioxidant capacity; autophagy; arsenic trioxide ... See more keywords
Arsenic trioxide or/and copper sulfate co-exposure induce glandular stomach of chicken injury via destruction of the mitochondrial dynamics and activation of apoptosis as well as autophagy.
Sign Up to like & getrecommendations! Published in 2019 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2019.109678
Abstract: Arsenic and copper are naturally occurring element. Contamination from natural processes and anthropogenic activities can be discovered all over the world and their unique interactions with the environment lead to widespread toxicity. When the content… read more here.
Keywords: copper sulfate; copper; glandular stomach; arsenic trioxide ... See more keywords
Dual oligopeptides modification mediates arsenic trioxide containing nanoparticles to eliminate primitive chronic myeloid leukemia cells inside bone marrow niches.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119179
Abstract: Chronic myeloid leukemia (CML) is one type of hematopoietic stem cell diseases. Although BCR-ABL1 tyrosine kinase inhibitors are remarkably effective in inducing remission in chronic phase patients, they are not curative in a majority of… read more here.
Keywords: marrow niches; arsenic trioxide; bone; dual oligopeptides ... See more keywords
Investigation of the ameliorative effects of baicalin against arsenic trioxide-induced cardiac toxicity in mice.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.108024
Abstract: Baicalin (BA), a kind of flavonoids compound, comes from Scutellaria baicalensis Georgi (a kind of perennial herb) and has beneficial effects on the cardiovascular system through anti-oxidant, anti-inflammation, and anti-apoptosis actions. However, the therapeutic effects… read more here.
Keywords: induced cardiac; arsenic trioxide; ato induced; cardiac toxicity ... See more keywords
Arsenic trioxide blocked proliferation and cardiomyocyte differentiation of human induced pluripotent stem cells: Implication in cardiac developmental toxicity.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2019.03.008
Abstract: Arsenic trioxide (ATO) has been recommended as the first-line agent for the treatment of acute promyelocytic leukaemia (APL), due to its substantial anticancer effect. Numerous clinical reports have indicated that ATO is a developmental toxicant… read more here.
Keywords: arsenic trioxide; human induced; differentiation; cardiac developmental ... See more keywords
'Prodrug-like' acetylmannosamine modified liposomes loaded with arsenic trioxide for the treatment of orthotopic glioma in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2020.06.001
Abstract: Glioma is one of the fatal intracranial cancers that is a huge challenge to decrease the death rate currently. The deep penetration and high accumulation of therapeutic inorganic ions into the tumor site are extremely… read more here.
Keywords: ac4man; glioma; arsenic trioxide; ato lip ... See more keywords
Low-Dose Arsenic Trioxide Modulates the Differentiation of Mouse Embryonic Stem Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.8b00027
Abstract: Arsenic (As) is a well-known environmental pollutant, while arsenic trioxide (ATO) has been proven to be an effective treatment for acute promyelocytic leukemia, however, the mechanism underlying its dual effects is not fully understood. Embryonic… read more here.
Keywords: low dose; arsenic trioxide; differentiation; embryonic stem ... See more keywords
Local delivery of arsenic trioxide nanoparticles for hepatocellular carcinoma treatment.
Sign Up to like & getrecommendations! Published in 2019 at "Signal transduction and targeted therapy"
DOI: 10.1038/s41392-019-0062-9
Abstract: Hepatocellular carcinoma (HCC) is a malignancy with a poor prognosis. Surgery combined with chemotherapy has been recommended as a curative regimen for HCC. Nevertheless, the anticancer mechanisms of chemicals in hepatocellular carcinoma remain unclear. Pyroptosis… read more here.
Keywords: hepatocellular carcinoma; trioxide nanoparticles; as2o3 nps; arsenic trioxide ... See more keywords
Arsenic trioxide-loaded nanoparticles enhance the chemosensitivity of gemcitabine in pancreatic cancer via the reversal of pancreatic stellate cell desmoplasia by targeting the AP4/galectin-1 pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm01039a
Abstract: Pancreatic stellate cells (PSCs) constitute the fibrotic tumor microenvironment composed of the stroma matrix, which blocks the penetration of gemcitabine (GEM) in pancreatic adenocarcinoma (PDAC) and results in chemoresistance. We analyzed the expression of α-SMA,… read more here.
Keywords: gem; pancreatic stellate; pancreatic cancer; ato ... See more keywords
L-Ascorbic Acid and α-Tocopherol Reduces Hepatotoxicity Associated with Arsenic Trioxide Chemotherapy by Modulating Nrf2 and Bcl2 Transcription Factors in Chang liver Cells
Sign Up to like & getrecommendations! Published in 2018 at "Nutrition and Cancer"
DOI: 10.1080/01635581.2018.1460676
Abstract: ABSTRACT Arsenic trioxide (As2O3) is a promising new regimen for the treatment of acute promyelocytic leukemia (APL). The induction of oxidative stress mediated by reactive oxygen species (ROS) and excessive intracellular calcium influx are the… read more here.
Keywords: chang liver; arsenic trioxide; acid tocopherol; ascorbic acid ... See more keywords