Ameliorative role of bosentan, an endothelin receptor antagonist, against sodium arsenite–induced renal dysfunction in rats
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-020-11035-0
Abstract: Arsenic exposure is well documented to cause serious health hazards, such as cardiovascular abnormalities, neurotoxicity and nephrotoxicity. In the present study, we intended to explore the role of bosentan, an endothelial receptor antagonist, against sodium… read more here.
Keywords: sodium arsenite; induced renal; role bosentan; arsenite induced ... See more keywords
Excessive Cu2+ deteriorates arsenite-induced apoptosis in chicken brain and resulting in immunosuppression, not in homeostasis.
Sign Up to like & getrecommendations! Published in 2019 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2019.124758
Abstract: Trace elements such as copper (Cu) and arsenic (As) are two of the major contaminants and well-known inducers of cognitive deficits and neurobehavioral changes. This study evaluated the immunotoxicity of their individual or combined exposure… read more here.
Keywords: apoptosis; cu2 deteriorates; deteriorates arsenite; excessive cu2 ... See more keywords
Calreticulin regulated intrinsic apoptosis through mitochondria-dependent and independent pathways mediated by ER stress in arsenite exposed HT-22 cells.
Sign Up to like & getrecommendations! Published in 2020 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2020.126466
Abstract: Arsenic is a naturally occurring environmental toxicant. Chronic exposure to arsenic is linked with neurological damage. Although the mechanisms remain to be elucidated, it is currently believed that neural cell apoptosis is one of the… read more here.
Keywords: apoptosis; mitochondria dependent; exposure; stress ... See more keywords
MicroRNA-155 regulates arsenite-induced malignant transformation by targeting Nrf2-mediated oxidative damage in human bronchial epithelial cells.
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2017.07.215
Abstract: Arsenite is a well-documented human lung carcinogen but the detailed mechanisms of carcinogenesis remain unclear. In this study, human bronchial epithelial (16-HBE) cells were continuously exposed to 2.5μM arsenite for about 13 weeks to induce… read more here.
Keywords: oxidative damage; malignant transformation; arsenite induced; human bronchial ... See more keywords
Quantitative Assessment of Arsenite-Induced Perturbation of Ubiquitinated Proteome.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00197
Abstract: Arsenic contamination in food and groundwater constitutes a public health concern for more than 200 million people worldwide. Individuals chronically exposed to arsenic through drinking and ingestion exhibit a higher risk of developing cancers and… read more here.
Keywords: arsenite induced; ubiquitinated proteome; ubiquitination; arsenite exposure ... See more keywords
Enhanced glycolysis, regulated by HIF-1&agr; via MCT-4, promotes inflammation in arsenite-induced carcinogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Carcinogenesis"
DOI: 10.1093/carcin/bgx034
Abstract: Arsenite is well established as a human carcinogen, but the molecular mechanisms leading to arsenite-induced carcinogenesis are complex and elusive. Accelerated glycolysis, a common process in tumor cells called the Warburg effect, is associated with… read more here.
Keywords: mct; glycolysis; induced carcinogenesis; enhanced glycolysis ... See more keywords
Hypermethylation of Mig-6 gene promoter region inactivates its function, leading to EGFR/ERK signaling hyperphosphorylation, and is involved in arsenite-induced hepatic stellate cells activation and extracellular matrix deposition.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of hazardous materials"
DOI: 10.2139/ssrn.4115282
Abstract: Arsenic is a widespread naturally contaminant. Previous studies have highlighted the issue of liver fibrosis induced by arsenic exposure, while the exact mechanisms are not yet fully understood. Recent studies suggest that Mig-6/EGFR/ERK signaling appear… read more here.
Keywords: erk signaling; activation; arsenite induced; hypermethylation ... See more keywords
Involvement of METTL3 in arsenite-induced skin lesions by targeting the SOCS3/STAT3/Krt signaling pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental pollution"
DOI: 10.2139/ssrn.4224039
Abstract: Arsenic is a common environmental pollutant, typically affecting the skin most severely. Recent studies have shown that arsenic's toxicity may be linked to N6-methyladenosine (m6A), an abundant and dynamic epigenetic RNA modification. However, it is… read more here.
Keywords: skin; arsenite induced; induced skin; stat3 ... See more keywords