Susceptibility to 3BNC117 and 10-1074 in ART suppressed chronically infected persons
Sign Up to like & getrecommendations! Published in 2023 at "AIDS"
DOI: 10.1097/qad.0000000000003575
Abstract: Objective: The aim of this study was to assess the susceptibility of HIV to two HIV monoclonal antibodies (bnAbs), 3BNC117 and 10-1074, in individuals with chronically antiretroviral therapy (ART) suppressed HIV infection. Design: The susceptibility… read more here.
Keywords: 3bnc117 1074; susceptibility; art suppressed; susceptibility 3bnc117 ... See more keywords
Subtype C HIV-1 reservoirs throughout the body in ART-suppressed individuals
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.162604
Abstract: Subtype B HIV-1 reservoirs have been intensively investigated, but reservoirs in other subtypes and how they respond to antiretroviral therapy (ART) is substantially less established. To characterize subtype C HIV-1 reservoirs, we implemented postmortem frozen,… read more here.
Keywords: hiv reservoirs; hiv; rna; art suppressed ... See more keywords
Robust Expansion of HIV CAR T Cells Following Antigen Boosting in ART-Suppressed Nonhuman Primates.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2020006372
Abstract: CAR T cells targeting CD19+ hematologic malignancies have rapidly emerged as a promising, novel therapy. In contrast, results from the few CAR T-cell studies for infectious diseases such as HIV-1 have been less convincing. These… read more here.
Keywords: art suppressed; expansion; antigen; car cells ... See more keywords
Deep Phenotypic Analysis of Blood and Lymphoid T and NK Cells From HIV+ Controllers and ART-Suppressed Individuals
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.803417
Abstract: T and natural killer (NK) cells are effector cells with key roles in anti-HIV immunity, including in lymphoid tissues, the major site of HIV persistence. However, little is known about the features of these effector… read more here.
Keywords: controllers art; suppressed individuals; phenotypic; art suppressed ... See more keywords