Baseline in vivo, ex vivo and molecular responses of Plasmodium falciparum to artemether and lumefantrine in three endemic zones for malaria in Colombia
Sign Up to like & getrecommendations! Published in 2017 at "Transactions of The Royal Society of Tropical Medicine and Hygiene"
DOI: 10.1093/trstmh/trx021
Abstract: Background Colombia began using artemisinin-based combination therapies for the treatment of uncomplicated Plasmodium falciparum malaria in 2006. It is necessary to implement resistance surveillance to antimalarial drugs in order to promptly detect changes in parasite… read more here.
Keywords: susceptibility; artemether lumefantrine; vivo; falciparum artemether ... See more keywords
Persistence of Residual Submicroscopic P. falciparum Parasitemia following Treatment of Artemether-Lumefantrine in Ethio-Sudan Border, Western Ethiopia
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DOI: 10.1128/aac.00002-22
Abstract: The emergence of artemisinin-resistant parasites in Africa has had a devastating impact, causing most malaria cases and related deaths reported on the continent. In Ethiopia, artemether-lumefantrine (AL) is the first-line drug for the treatment of… read more here.
Keywords: day; artemether lumefantrine; falciparum; residual submicroscopic ... See more keywords
Efficacy of Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated Plasmodium falciparum Malaria among Children in Western Kenya, 2016 to 2017
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DOI: 10.1128/aac.00207-22
Abstract: Antimalarial resistance threatens global malaria control efforts. The World Health Organization (WHO) recommends routine antimalarial efficacy monitoring through a standardized therapeutic efficacy study (TES) protocol. ABSTRACT Antimalarial resistance threatens global malaria control efforts. The World… read more here.
Keywords: day; lumefantrine dihydroartemisinin; efficacy; artemether lumefantrine ... See more keywords
Differential Impact of Nevirapine on Artemether-Lumefantrine Pharmacokinetics in Individuals Stratified by CYP2B6 c.516G>T Genotypes
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DOI: 10.1128/aac.00947-19
Abstract: There is an increased recognition of the need to identify and quantify the impact of genetic polymorphisms on drug-drug interactions. This study investigated the pharmacogenetics of the pharmacokinetic drug-drug interaction between nevirapine and artemether-lumefantrine in… read more here.
Keywords: nevirapine artemether; drug; artemether lumefantrine; hiv ... See more keywords
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Coadministered Ruxolitinib and Artemether-Lumefantrine in Healthy Adults
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DOI: 10.1128/aac.01584-21
Abstract: Despite repeated malaria infection, individuals living in areas where malaria is endemic remain vulnerable to reinfection. The Janus kinase (JAK1/2) inhibitor ruxolitinib could potentially disrupt the parasite-induced dysfunctional immune response when administered with antimalarial therapy.… read more here.
Keywords: artemether lumefantrine; ruxolitinib; safety tolerability; placebo ... See more keywords
Continued Low Efficacy of Artemether-Lumefantrine in Angola in 2019
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DOI: 10.1128/aac.01949-20
Abstract: Biennial therapeutic efficacy monitoring is a crucial activity for ensuring the efficacy of currently used artemisinin-based combination therapy in Angola. Children with acute uncomplicated Plasmodium falciparum infection in sentinel sites in the Benguela, Zaire, and… read more here.
Keywords: angola; efficacy; artemether lumefantrine; lunda sul ... See more keywords
pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom
Sign Up to like & getrecommendations! Published in 2017 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02382-16
Abstract: ABSTRACT We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent symptoms and Plasmodium falciparum parasitemia within 6 weeks of… read more here.
Keywords: treated artemether; artemether lumefantrine; treatment; plasmodium falciparum ... See more keywords
Reduced ex vivo susceptibility of Plasmodium falciparum after oral artemether–lumefantrine treatment in Mali
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DOI: 10.1186/s12936-017-1700-8
Abstract: BackgroundArtemisinin-based combination therapy is the recommended first-line treatment for uncomplicated falciparum malaria worldwide. However, recent studies conducted in Mali showed an increased frequency of recurrent parasitaemia following artemether–lumefantrine (AL) treatment.MethodsStudy samples were collected during a… read more here.
Keywords: artemether lumefantrine; lumefantrine treatment; mali; treatment ... See more keywords
Electrocardiographic safety evaluation of extended artemether-lumefantrine treatment in patients with uncomplicated Plasmodium falciparum malaria in Bagamoyo District, Tanzania
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DOI: 10.1186/s12936-020-03309-2
Abstract: Extended artemisinin-based combination therapy (ACT) for treatment of uncomplicated Plasmodium falciparum malaria with already existing drug regimens, such as artemether-lumefantrine, might be effective in tackling the emerging ACT resistance. However, given the history of cardiotoxicity… read more here.
Keywords: qtc; artemether lumefantrine; extended artemether; treatment ... See more keywords
Asymptomatic recrudescence after artemether–lumefantrine treatment for uncomplicated falciparum malaria: a systematic review and meta-analysis
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DOI: 10.1186/s12936-020-03520-1
Abstract: Background In clinical trials of therapy for uncomplicated Plasmodium falciparum, there are usually some patients who fail treatment even in the absence of drug resistance. Treatment failures, which can be due to recrudescence or re-infection,… read more here.
Keywords: asymptomatic recrudescence; uncomplicated falciparum; artemether lumefantrine; treatment ... See more keywords
Anti-malarial efficacy and resistance monitoring of artemether-lumefantrine and dihydroartemisinin-piperaquine shows inadequate efficacy in children in Burkina Faso, 2017–2018
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DOI: 10.1186/s12936-021-03585-6
Abstract: Background The World Health Organization recommends regularly assessing the efficacy of artemisinin-based combination therapy (ACT), which is a critical tool in the fight against malaria. This study evaluated the efficacy of two artemisinin-based combinations recommended… read more here.
Keywords: burkina faso; artemether lumefantrine; efficacy; lumefantrine dihydroartemisinin ... See more keywords