Physical ARTEMIS:DNA-PKcs interaction is necessary for V(D)J recombination
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DOI: 10.1093/nar/gkac071
Abstract: Abstract The nuclease ARTEMIS and the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) are involved in the repair of physiological and pathogenic DNA double strand breaks. Both proteins are indispensable for the hairpin-opening activity in V(D)J… read more here.
Keywords: dna pkcs; interaction; dna; artemis dna ... See more keywords
Structural analysis of the basal state of the Artemis:DNA-PKcs complex
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac564
Abstract: Abstract Artemis nuclease and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) are key components in nonhomologous DNA end joining (NHEJ), the major repair mechanism for double-strand DNA breaks. Artemis activation by DNA-PKcs resolves hairpin DNA ends… read more here.
Keywords: dna; artemis dna; dna pkcs; pkcs complex ... See more keywords