Targeting autophagy enhances the anticancer effect of artemisinin and its derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Research Reviews"
DOI: 10.1002/med.21580
Abstract: Artemisinin and its derivatives, with their outstanding clinical efficacy and safety, represent the most effective and impactful antimalarial drugs. Apart from its antimalarial effect, artemisinin has also been shown to exhibit selective anticancer properties against… read more here.
Keywords: cancer; artemisinin; effect artemisinin; anticancer ... See more keywords
Enhancing the antimalarial activity of artesunate
Sign Up to like & getrecommendations! Published in 2020 at "Parasitology Research"
DOI: 10.1007/s00436-020-06786-1
Abstract: The global challenge to the treatment of malaria is mainly the occurrence of resistance of malaria parasites to conventionally used antimalarials. Artesunate, a semisynthetic artemisinin compound, and other artemisinin derivatives are currently used in combination… read more here.
Keywords: enhancing antimalarial; antimalarial activity; resistance; artemisinin ... See more keywords
Dihydroartemisinin, an active metabolite of artemisinin, interferes with Leishmania braziliensis mitochondrial bioenergetics and survival.
Sign Up to like & getrecommendations! Published in 2021 at "Parasitology research"
DOI: 10.1007/s00436-020-07019-1
Abstract: Leishmaniasis is one of the most neglected parasitic infections of the world and current therapeutic options show several limitations. In the search for more effective drugs, plant compounds represent a powerful natural source. Artemisinin is… read more here.
Keywords: leishmania braziliensis; mitochondrial bioenergetics; dqhs; artemisinin ... See more keywords
Molecular insights into AabZIP1-mediated regulation on artemisinin biosynthesis and drought tolerance in Artemisia annua
Sign Up to like & getrecommendations! Published in 2021 at "Acta Pharmaceutica Sinica B"
DOI: 10.1016/j.apsb.2021.09.026
Abstract: Abstract Artemisia annua is the main natural source of artemisinin production. In A. annua, extended drought stress severely reduces its biomass and artemisinin production while short-term water-withholding or abscisic acid (ABA) treatment can increase artemisinin… read more here.
Keywords: biosynthesis; artemisinin biosynthesis; drought tolerance; artemisia annua ... See more keywords
Structural optimization and biological evaluation for novel artemisinin derivatives against liver and ovarian cancers.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.113000
Abstract: An increasing number of artemisinin (ARS) and its derivatives have been reported for their potential therapeutic value of human cancer. However, their therapeutic potencies are limited owing to their poor pharmacokinetic profiles. Our previous studies… read more here.
Keywords: optimization biological; ovarian cancer; artemisinin; structural optimization ... See more keywords
Absence of association between polymorphisms in the K13 gene and the presence of Plasmodium falciparum parasites at day 3 after treatment with artemisinin derivatives in Senegal.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2017.01.032
Abstract: In 2006, the Senegalese National Malaria Control Programme recommended artemisinin-based combination therapy as first-line treatment for uncomplicated malaria. In addition, intravenous (i.v.) injection of artesunate and artemether has gradually replaced quinine for the treatment of… read more here.
Keywords: treatment; plasmodium falciparum; artemisinin; gene ... See more keywords
Absence of association between polymorphisms in the pfcoronin and pfk13 genes and the presence of Plasmodium falciparum parasites after treatment with artemisinin derivatives in Senegal.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2020.106190
Abstract: Due to resistance to chloroquine and sulfadoxine-pyrimethamine, treatment for uncomplicated Plasmodium falciparum malaria switched to artemisinin-based combination therapy (ACT) in 2006 in Senegal. Several mutations in the gene coding the kelch13 helix (pfk13-propeller) were identified… read more here.
Keywords: pfcoronin pfk13; treatment; association; plasmodium falciparum ... See more keywords
Enhancing growth, productivity and artemisinin content of Artemisia annua L. Plant using seaweed extract and micronutrients
Sign Up to like & getrecommendations! Published in 2021 at "Industrial Crops and Products"
DOI: 10.1016/j.indcrop.2020.113202
Abstract: Abstract The farmers' improper use of chemicals and inorganic fertilizers to plant improve growth and productivity is harmful to the environment and human health. The use of bio-stimulants such as seaweed extract in agriculture could… read more here.
Keywords: plant; artemisia annua; seaweed extract; growth productivity ... See more keywords
New Insights into the Spread of Resistance to Artemisinin and its Analogues.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2021.09.001
Abstract: The causative agent of malaria, Plasmodium falciparum, has been developing resistance to several drugs worldwide since more than five decades. Initially, resistance was toward drugs such as chloroquine, pyrimethamine, sulfadoxine, mefloquine, and quinine. Research studies… read more here.
Keywords: spread resistance; resistance artemisinin; insights spread; resistance ... See more keywords
Bioactive half-sandwich Rh and Ir bipyridyl complexes containing artemisinin.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2021.111408
Abstract: Reaction of dihydroartemisinin (DHA) with 4-methyl-4'-carboxy-2,2'-bipyridine yielded the new ester derivative L1. Six novel organometallic half-sandwich chlorido Rh(III) and Ir(III) complexes (1-6) containing pentamethylcyclopentadienyl, (Cp*), tetramethylphenylcyclopentadienyl (Cpxph), or tetramethylbiphenylcyclopentadienyl (Cpxbiph), and N,N-chelated bipyridyl group of… read more here.
Keywords: sandwich bipyridyl; bioactive half; artemisinin; complexes containing ... See more keywords
Screening of alternative solvent ionic liquids for artemisinin: COSMO-RS prediction and experimental verification
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2021.116778
Abstract: Abstract Organic solvents are usually used to extract artemisinin from Artemisia annua L., and they can also be the solvents for the subsequent purification or derivatization to produce compounds with more efficient antimalarial effect. However,… read more here.
Keywords: solvent ionic; emim; artemisinin; alternative solvent ... See more keywords