Antimalarial artemisinin-based combination therapies (ACT) and COVID-19 in Africa: In vitro inhibition of SARS-CoV-2 replication by mefloquine-artesunate
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Infectious Diseases"
DOI: 10.1016/j.ijid.2020.08.032
Abstract: Abstract Objectives At the end of November 2019, a novel coronavirus responsible for respiratory tract infections (COVID-19) emerged in China. Despite drastic containment measures, this virus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),… read more here.
Keywords: mefloquine artesunate; inhibition; based combination; artemisinin based ... See more keywords
Artemisinin-based combination therapy (ACT) and drug resistance molecular markers: A systematic review of clinical studies from two malaria endemic regions – India and sub-Saharan Africa
Sign Up to like & getrecommendations! Published in 2020 at "International Journal for Parasitology: Drugs and Drug Resistance"
DOI: 10.1016/j.ijpddr.2020.11.006
Abstract: Artemisinin-based combination therapies (ACT) are currently used as a first-line malaria therapy in endemic countries worldwide. This systematic review aims at presenting the current scenario of drug resistance molecular markers, either selected or involved in… read more here.
Keywords: drug resistance; based combination; review; resistance ... See more keywords
Molecular Surveillance of Artemisinin-Based Combination Therapies Resistance in Plasmodium falciparum Parasites from Bioko Island, Equatorial Guinea
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DOI: 10.1128/spectrum.00413-22
Abstract: Malaria, one of the tropical parasitic diseases with a high transmission rate in Bioko Island, Equatorial Guinea, especially caused by P. falciparum is highly prevalent in this region and is commonly treated locally with ACTs.… read more here.
Keywords: pfk13; equatorial guinea; artemisinin; artemisinin based ... See more keywords
Naturally Acquired Kelch13 Mutations in Plasmodium falciparum Strains Modulate In Vitro Ring-Stage Artemisinin-Based Drug Tolerance and Parasite Survival in Response to Hyperoxia
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01282-21
Abstract: Artemisinin-based combination therapy (ACT) for treating malaria is under intense scrutiny following treatment failures in the Greater Mekong subregion of Asia. This is further compounded by the potential for extensive loss of life if treatment… read more here.
Keywords: artemisinin based; tolerance; kelch13 mutations; treatment ... See more keywords
Watching the availability and use of rapid diagnostic tests (RDTs) and artemisinin-based combination therapy (ACT)
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DOI: 10.1186/s12936-017-1821-0
Abstract: At the turn of this new century and after much debate, the malaria community reckoned with failing first line therapies and moved to a global recommendation for deployment of an artemisinin-based combination therapy (ACT) to… read more here.
Keywords: diagnosis treatment; based combination; therapy act; artemisinin based ... See more keywords
Molecular surveillance over 14 years confirms reduction of Plasmodium vivax and falciparum transmission after implementation of Artemisinin-based combination therapy in Papua, Indonesia
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0008295
Abstract: Genetic epidemiology can provide important insights into parasite transmission that can inform public health interventions. The current study compared long-term changes in the genetic diversity and structure of co-endemic Plasmodium falciparum and P. vivax populations.… read more here.
Keywords: transmission; papua indonesia; falciparum; based combination ... See more keywords
To what extent are the antimalarial markets in African countries ready for a transition to triple artemisinin-based combination therapies?
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DOI: 10.1371/journal.pone.0256567
Abstract: Introduction Triple artemisinin-based combination therapies (TACTs) are being developed as a response to artemisinin and partner drug resistance in the treatment of falciparum malaria in Southeast Asia. In African countries, where current artemisinin-based combination therapies… read more here.
Keywords: combination therapies; based combination; artemisinin based; artemisinin ... See more keywords
Ethical considerations in deploying triple artemisinin-based combination therapies for malaria: An analysis of stakeholders’ perspectives in Burkina Faso and Nigeria
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DOI: 10.1371/journal.pone.0273249
Abstract: Background Artemisinin-based combination therapies (ACTs) are the recommended treatment for uncomplicated Plasmodium falciparum malaria in all malaria endemic countries. Artemisinin resistance, partner drug resistance, and subsequent ACT failure are widespread in Southeast Asia. The more… read more here.
Keywords: combination therapies; based combination; triple artemisinin; resistance ... See more keywords
The Effect of Artemisinin-Based Drugs vs Non-artemisinin-based Drugs on Gametophyte Carrying in the Body After the Treatment of Uncomplicated Falciparum Malaria: A Systematic Review and Meta-analysis
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DOI: 10.3389/fphar.2021.707498
Abstract: The WHO recommends Artemisinin-based combination therapy (ACTs) as the first-line treatment for malaria. This meta-analysis aims to analyze the effects of artemisinin and its derivatives as well as non-artemisinin drugs on the gametophytes in the… read more here.
Keywords: artemisinin based; treatment; based drugs; meta analysis ... See more keywords
Artemisinin-Based Antimalarial Drug Therapy: Molecular Pharmacology and Evolving Resistance
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DOI: 10.3390/tropicalmed4020089
Abstract: The molecular pharmacology of artemisinin (ART)-based antimalarial drugs is incompletely understood. Clinically, these drugs are used in combination with longer lasting partner drugs in several different artemisinin combination therapies (ACTs). ACTs are currently the standard… read more here.
Keywords: based antimalarial; molecular pharmacology; pharmacology; resistance ... See more keywords