The current scenario on anticancer activity of artemisinin metal complexes, hybrids, and dimers
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200086
Abstract: Cancer, the most significant cause of morbidity and mortality, has already posed a heavy burden on health care systems globally. In recent years, cancer treatment has made a significant breakthrough, but cancer cells inevitably acquire… read more here.
Keywords: anticancer activity; artemisinin derivatives; current scenario; anticancer ... See more keywords
Targeting autophagy enhances the anticancer effect of artemisinin and its derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Research Reviews"
DOI: 10.1002/med.21580
Abstract: Artemisinin and its derivatives, with their outstanding clinical efficacy and safety, represent the most effective and impactful antimalarial drugs. Apart from its antimalarial effect, artemisinin has also been shown to exhibit selective anticancer properties against… read more here.
Keywords: cancer; artemisinin; effect artemisinin; anticancer ... See more keywords
Research Progress on Artemisinin and Its Derivatives against Hematological Malignancies
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Journal of Integrative Medicine"
DOI: 10.1007/s11655-019-3207-3
Abstract: Although current therapeutic methods against hematological malignancies are effective in the early stage, they usually lose their effectiveness because of the development of drug resistances. Seeking new drugs with significant therapeutic effects is one of… read more here.
Keywords: progress artemisinin; research; derivatives hematological; hematological malignancies ... See more keywords
Computational Analysis of Artimisinin Derivatives on the Antitumor Activities
Sign Up to like & getrecommendations! Published in 2017 at "Natural Products and Bioprospecting"
DOI: 10.1007/s13659-017-0142-x
Abstract: The study on antitumor activities of artemisinin and its derivatives has been closely focused on in recent years. Herein, 2D and 3D QSAR analysis was performed on the basis of a series of artemisinin derivatives… read more here.
Keywords: artimisinin derivatives; antitumor activities; analysis; computational analysis ... See more keywords
Absence of association between polymorphisms in the K13 gene and the presence of Plasmodium falciparum parasites at day 3 after treatment with artemisinin derivatives in Senegal.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2017.01.032
Abstract: In 2006, the Senegalese National Malaria Control Programme recommended artemisinin-based combination therapy as first-line treatment for uncomplicated malaria. In addition, intravenous (i.v.) injection of artesunate and artemether has gradually replaced quinine for the treatment of… read more here.
Keywords: treatment; plasmodium falciparum; artemisinin; gene ... See more keywords
Absence of association between polymorphisms in the pfcoronin and pfk13 genes and the presence of Plasmodium falciparum parasites after treatment with artemisinin derivatives in Senegal.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2020.106190
Abstract: Due to resistance to chloroquine and sulfadoxine-pyrimethamine, treatment for uncomplicated Plasmodium falciparum malaria switched to artemisinin-based combination therapy (ACT) in 2006 in Senegal. Several mutations in the gene coding the kelch13 helix (pfk13-propeller) were identified… read more here.
Keywords: pfcoronin pfk13; treatment; association; plasmodium falciparum ... See more keywords
The Potential Mechanisms by which Artemisinin and Its Derivatives Induce Ferroptosis in the Treatment of Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/1458143
Abstract: Artemisinin (ART) is a bioactive molecule derived from the Chinese medicinal plant Artemisia annua (Asteraceae). ART and artemisinin derivatives (ARTs) have been effectively used for antimalaria treatment. The structure of ART is composed of a… read more here.
Keywords: derivatives induce; artemisinin derivatives; mechanisms artemisinin; potential mechanisms ... See more keywords
Therapeutic potential of artemisinin and its derivatives in managing kidney diseases
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1097206
Abstract: Artemisinin, an antimalarial traditional Chinese herb, is isolated from Artemisia annua. L, and has shown fewer side effects. Several pieces of evidence have demonstrated that artemisinin and its derivatives exhibited therapeutic effects on diseases like… read more here.
Keywords: therapeutic potential; potential artemisinin; kidney diseases; kidney ... See more keywords
Enhancing activity of β-lactam and fluoroquinolones antibiotics by artemisinin and its derivatives against MDR Escherichia coli
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2022.1048531
Abstract: Artemisinin and its derivatives had played a biocidal role in biomedical remedies, while they were expected to enhance the activity of antibiotics against multiple drug-resistant (MDR) bacteria. The current study evaluated the interaction of artemisinin… read more here.
Keywords: escherichia coli; artemisinin derivatives; activity; fluoroquinolones antibiotics ... See more keywords
Artemisinin and Derivatives-Based Hybrid Compounds: Promising Therapeutics for the Treatment of Cancer and Malaria.
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26247521
Abstract: Cancer and malaria are major health conditions around the world despite many strategies and therapeutics available for their treatment. The most used strategy for the treatment of these diseases is the administration of therapeutic drugs,… read more here.
Keywords: hybrid compounds; cancer malaria; treatment cancer; artemisinin derivatives ... See more keywords
Artemisinin Derivatives Inhibit Non-small Cell Lung Cancer Cells Through Induction of ROS-dependent Apoptosis/Ferroptosis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cancer"
DOI: 10.7150/jca.57054
Abstract: Non-small cell lung cancer (NSCLC) is one of the major cancer-related causes of morbidity and mortality worldwide. Despite the progress in lung cancer treatment, there is still an urgent need to discover novel therapeutic agents… read more here.
Keywords: lung cancer; ferroptosis; artemisinin derivatives; cancer ... See more keywords