An Update on Artemisinin Resistance.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9550-9_10
Abstract: While the precise mode of action of artemisinin (ART) derivatives remains obscure, it is nonetheless commonly accepted that ART generates reactive oxygen intermediates that contribute to cell death. Also, numerous studies confirm that point mutations… read more here.
Keywords: update artemisinin; artemisinin resistance; resistance; biology ... See more keywords
Mechanisms of artemisinin resistance in Plasmodium falciparum malaria
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2018.06.003
Abstract: &NA; Artemisinin‐based combination therapies (ACTs) have substantially reduced worldwide malaria burden and deaths. But malaria parasites have become resistant to artemisinins. Prior studies suggested two different molecular pathways of artemisinin‐resistance. Here we unify recent findings… read more here.
Keywords: malaria; resistance plasmodium; mechanisms artemisinin; artemisinin resistance ... See more keywords
Integration of population and functional genomics to understand mechanisms of artemisinin resistance in Plasmodium falciparum
Sign Up to like & getrecommendations! Published in 2021 at "International Journal for Parasitology: Drugs and Drug Resistance"
DOI: 10.1016/j.ijpddr.2021.05.006
Abstract: Resistance to antimalarial drugs, and in particular to the artemisinin derivatives and their partner drugs, threatens recent progress toward regional malaria elimination and eventual global malaria eradication. Population-level studies utilizing whole-genome sequencing approaches have facilitated… read more here.
Keywords: population; artemisinin resistance; resistance; plasmodium falciparum ... See more keywords
P. falciparum artemisinin resistance: the effect of heme, protein damage, and parasite cell stress response.
Sign Up to like & getrecommendations! Published in 2020 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.9b00527
Abstract: Despite a significant decline in morbidity and mortality over the last two decades, in 2018 there were 228 million reported cases of malaria and 405,000 malaria-related deaths. Artemisinin, the cornerstone of artemisinin-based combination therapies, is… read more here.
Keywords: protein; heme; artemisinin resistance; resistance ... See more keywords
The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background
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DOI: 10.1038/s41467-018-07588-x
Abstract: The predisposition of parasites acquiring artemisinin resistance still remains unclear beyond the mutations in Pfk13 gene and modulation of the unfolded protein response pathway. To explore the chain of casualty underlying artemisinin resistance, we reanalyze… read more here.
Keywords: origins malaria; malaria artemisinin; artemisinin resistance; resistance ... See more keywords
Comparative structural and evolutionary analyses predict functional sites in the artemisinin resistance malaria protein K13
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-47034-6
Abstract: Numerous mutations in the Plasmodium falciparum Kelch13 (K13) protein confer resistance to artemisinin derivatives, the current front-line antimalarial drugs. K13 is an essential protein that contains BTB and Kelch-repeat propeller (KREP) domains usually found in… read more here.
Keywords: protein; comparative structural; k13; artemisinin resistance ... See more keywords
Antimalarial Drug Resistance: A Threat to Malaria Elimination.
Sign Up to like & getrecommendations! Published in 2017 at "Cold Spring Harbor perspectives in medicine"
DOI: 10.1101/cshperspect.a025619
Abstract: Increasing antimalarial drug resistance once again threatens effective antimalarial drug treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are first-line treatment for uncomplicated falciparum malaria in all endemic countries, yet partial resistance to artemisinins… read more here.
Keywords: drug resistance; antimalarial drug; drug; artemisinin resistance ... See more keywords
Assessment of Plasmodium falciparum Artemisinin Resistance Independent of kelch13 Polymorphisms and with Escalating Malaria in Bangladesh
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DOI: 10.1128/mbio.03444-21
Abstract: Malaria elimination is a Millennium Development Goal. Artemisinins, fast-acting antimalarial drugs, have played a key role in malaria elimination. ABSTRACT Emerging resistance to artemisinin drugs threatens the elimination of malaria. Resistance is widespread in South… read more here.
Keywords: resistance; artemisinin; malaria elimination; plasmodium falciparum ... See more keywords
Prevalence of molecular markers of sulfadoxine–pyrimethamine and artemisinin resistance in Plasmodium falciparum from Pakistan
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DOI: 10.1186/s12936-018-2620-y
Abstract: BackgroundIn Pakistan, artesunate (AS) in combination with sulfadoxine–pyrimethamine (SP) is the recommended treatment for uncomplicated Plasmodium falciparum malaria. Monitoring molecular markers of anti-malarial drug resistance is crucial for early detection and containment of parasite resistance… read more here.
Keywords: falciparum; prevalence; artemisinin resistance; molecular markers ... See more keywords
Malaria profiles and challenges in artemisinin resistance containment in Myanmar
Sign Up to like & getrecommendations! Published in 2017 at "Infectious Diseases of Poverty"
DOI: 10.1186/s40249-017-0292-4
Abstract: BackgroundThis study examined evolving malaria profiles from January, 2010 to December, 2014 to evaluate achievements and challenges of implementing measures to prevent and control spread of artemisinin resistance in Myanmar.MethodsUsing National Malaria Control Programme (NMCP)… read more here.
Keywords: malaria; containment; myanmar; malaria profiles ... See more keywords
Screening for antifolate and artemisinin resistance in Plasmodium falciparum clinical isolates from three hospitals of Eritrea
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DOI: 10.12688/f1000research.54195.1
Abstract: Background: Antimalarial drug resistance is a major challenge hampering malaria control and elimination. Plasmodium falciparum, the leading causative parasite species, has developed resistance to basically all antimalarials. Continued surveillance of drug resistance using genetic markers… read more here.
Keywords: artemisinin resistance; plasmodium falciparum; falciparum clinical; resistance ... See more keywords