Targeting Artemisinin-Resistant Malaria by Repurposing the Anti-Hepatitis C Virus Drug Alisporivir
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DOI: 10.1128/aac.00392-22
Abstract: The emergence of Plasmodium falciparum resistance raises an urgent need to find new antimalarial drugs. Here, we report the rational repurposing of the anti-hepatitis C virus drug, alisporivir, a nonimmunosuppressive analog of cyclosporin A, against… read more here.
Keywords: alisporivir; anti hepatitis; artemisinin resistant; repurposing anti ... See more keywords
Polymorphisms in the K13-Propeller Gene in Artemisinin-Resistant Plasmodium in Mice
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DOI: 10.2147/idr.s383127
Abstract: Introduction Artemisinin-based combination therapies (ACTs) act as first-line antimalarial drugs and play a crucial role in the successful control of falciparum malaria. However, the recent emergence of resistance of Plasmodium falciparum to ACTs in South… read more here.
Keywords: artemisinin resistant; plasmodium; artemisinin; resistance ... See more keywords
Artemisinin-Resistant Plasmodium falciparum with High Survival Rates, Uganda, 2014–2016
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DOI: 10.3201/eid2404.170141
Abstract: Because ≈90% of malaria cases occur in Africa, emergence of artemisinin-resistant Plasmodium falciparum in Africa poses a serious public health threat. To assess emergence of artemisinin-resistant parasites in Uganda during 2014–2016, we used the recently… read more here.
Keywords: 2014 2016; uganda 2014; resistant plasmodium; plasmodium falciparum ... See more keywords