Pannexin 1 channels control CaV1.2 channel activity and vascular reactivity in diabetic hyperglycemia
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731650
Abstract: Vascular complications are major causes of morbidity and mortality in diabetic patients. Recently, our group identified a novel purinergic signaling pathway involving the AKAP5/P2Y11/AC5/PKA/CaV1.2 protein network in arterial myocytes that is activated upon diabetic hyperglycemia… read more here.
Keywords: vascular reactivity; diabetic hyperglycemia; arterial myocytes; activity vascular ... See more keywords
Trafficking of BK channel subunits controls arterial contractility
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DOI: 10.18632/oncotarget.22280
Abstract: Plasma membrane ion channels modulate the physiological functions of virtually all cell types, including vascular smooth muscle cells (myocytes) [1]. Many ion channels are composed of both pore-forming and auxiliary subunits, with the conventional view… read more here.
Keywords: surface; channel subunits; channel; ion ... See more keywords
Long-Term Hypoxia Negatively Influences Ca2+ Signaling in Basilar Arterial Myocytes of Fetal and Adult Sheep
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.760176
Abstract: Cerebral arterial vasoreactivity is vital to the regulation of cerebral blood flow. Depolarization of arterial myocytes elicits whole-cell Ca2+ oscillations as well as subcellular Ca2+ sparks due to activation of ryanodine receptors on the sarcoplasmic… read more here.
Keywords: ca2 signaling; whole cell; long term; ca2 ... See more keywords